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广藿香精油会改变成年哺乳动物的血小板单胺氧化酶 -A 活性吗?

Does patchouli oil change blood platelet monoamine oxidase-A activity of adult mammals?

作者信息

Karim Md Fazlul, Banerjee Soumyabrata, Poddar Mrinal K

机构信息

Department of Biochemistry, University of Calcutta, 35, B.C. Road, Kolkata, 700019, India.

出版信息

J Physiol Sci. 2018 May;68(3):281-291. doi: 10.1007/s12576-017-0534-z. Epub 2017 Apr 1.

Abstract

Patchouli oil, an essential aroma oil extracted from patchouli leaf during short-term exposure with five and ten drops either inhibited (at 1 or 2 h) or stimulated (at 4 h) the platelet MAO-A activity depending on the dosages of the aroma oil mainly due to inhibition or stimulation of its K . The long-term 15 consecutive days exposure (with two or five drops) of patchouli oil, on the other hand, maximally stimulated the platelet MAO-A activity with five drops patchouli oil for 1 h exposure, but further continuation of its exposure with same doses (two or five drops) for 30 consecutive days significantly stimulated (with two drops) and inhibited (with five drops) the platelet MAO-A activity due to stimulation and inhibition respectively of its corresponding both K and V . These results thus suggest that this aroma oil exposure may modulate the blood platelet serotonergic regulation depending on the dose, duration, and conditions of exposure.

摘要

广藿香油是一种从广藿香叶中提取的香精油,在短期接触时,五滴和十滴广藿香油根据香精油的剂量,在1或2小时时抑制血小板单胺氧化酶A(MAO-A)活性,在4小时时刺激该活性,这主要是由于其钾离子的抑制或刺激作用。另一方面,连续15天长期接触(两滴或五滴)广藿香油,五滴广藿香油暴露1小时可最大程度地刺激血小板MAO-A活性,但以相同剂量(两滴或五滴)继续连续暴露30天,则分别由于其相应的钾离子和最大反应速度(V)的刺激和抑制作用,显著刺激(两滴)和抑制(五滴)血小板MAO-A活性。因此,这些结果表明,这种香精油暴露可能根据剂量、持续时间和暴露条件调节血小板5-羟色胺能调节。

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