Zhang Ruoqi, Yan Peiao, Li Yunxia, Xiong Liang, Gong Xiaohong, Peng Cheng
Pharmacy College, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Avenue, Chengdu, 611137, People's Republic of China.
Eur J Drug Metab Pharmacokinet. 2016 Aug;41(4):441-8. doi: 10.1007/s13318-015-0272-7. Epub 2015 Mar 10.
Pogostemonis herba is used in traditional Chinese medicine to remove dampness, relieve sunstroke, stop vomiting and increase appetite. Patchouli alcohol, an ingredient in pogostemonis herba, has the potential to treat inflammation as well as bacterial and fungal infections. The essential oil of pogostemonis herba (patchouli oil) is commonly given orally in clinical settings; however, no pharmacokinetic studies have examined its oral administration. The goal of this study was to investigate the pharmacokinetic behavior of patchouli alcohol following single-dose oral administration in rats; the influence of other patchouli oil components on the pharmacokinetic profile of patchouli alcohol was also examined. In this study, a simple and selective GC/MS method was developed and validated to measure the level of patchouli alcohol in rat plasma. The study revealed that the pharmacokinetics profile was linear in both the patchouli alcohol and patchouli oil groups. The C max and AUC0-t of patchouli alcohol were greater in all three doses of patchouli alcohol compared to corresponding patchouli oil doses. Additionally, the T max values were significantly greater in the patchouli oil group. These results suggest that the other ingredients in patchouli oil influence the pharmacokinetic behavior of patchouli alcohol during its absorption. The results provide a meaningful basis for evaluating the clinical application of patchouli oil and patchouli alcohol.
广藿香在传统中药中用于祛湿、解暑、止呕和增进食欲。广藿香醇是广藿香中的一种成分，具有治疗炎症以及细菌和真菌感染的潜力。广藿香油（广藿香精油）在临床环境中通常口服给药；然而，尚无药代动力学研究考察其口服给药情况。本研究的目的是研究大鼠单剂量口服给药后广藿香醇的药代动力学行为；还考察了广藿香油其他成分对广藿香醇药代动力学特征的影响。在本研究中，建立并验证了一种简单且选择性的气相色谱/质谱法来测定大鼠血浆中广藿香醇的水平。研究表明，广藿香醇组和广藿香油组的药代动力学特征均呈线性。与相应的广藿香油剂量相比，所有三个广藿香醇剂量下广藿香醇的Cmax和AUC0-t均更高。此外，广藿香油组的Tmax值显著更高。这些结果表明，广藿香油中的其他成分在广藿香醇吸收过程中影响其药代动力学行为。这些结果为评估广藿香油和广藿香醇的临床应用提供了有意义的依据。
