Kimura Yoshihide, Kamiya Takeshi, Senoo Kyouji, Tsuchida Kenji, Hirano Atsuyuki, Kojima Hisayo, Yamashita Hiroaki, Yamakawa Yoshihiro, Nishigaki Nobuhiro, Ozeki Tomonori, Endo Masatsugu, Nakanishi Kazuhisa, Sando Motoki, Inagaki Yusuke, Shikano Michiko, Mizoshita Tsutomu, Kubota Eiji, Tanida Satoshi, Kataoka Hiromi, Katsumi Kohei, Joh Takashi
Department of Gastroenterology, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, Japan.
Department of Medical Innovation, Nagoya City University Graduate School of Medical Sciences, 1 Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
J Clin Biochem Nutr. 2016 Jul;59(1):71-7. doi: 10.3164/jcbn.16-9. Epub 2016 May 21.
Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders. Their health-related quality of life was then evaluated using the 8-item Short Form Health Survey, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale questionnaires. Sixty-nine patients (47.6%) were partial responders. These patients had significantly lower scores than responders in 5/8 subscales and in the mental health component summary of the 8-item Short Form Health Survey. Partial responders had significantly higher Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale scores, including anxiety and depression scores, than those of responders. Non-erosive reflux disease and double proton pump inhibitor doses were predictive factors of partial responders. Persistent reflux symptoms, despite proton pump inhibitor therapy, caused mental health disorders, sleep disorders, and psychological distress in Japanese gastroesophageal reflux disease patients.
一些胃食管反流病患者尽管接受了质子泵抑制剂治疗，但仍有持续的反流症状。这些症状降低了他们与健康相关的生活质量。我们的目的是评估质子泵抑制剂疗效与健康相关生活质量之间的关系，并评估影响日本患者治疗反应的预测因素。使用胃食管反流病问卷，对145名接受质子泵抑制剂治疗的胃食管反流病患者进行评估，并分为反应者或部分反应者。然后使用8项简短健康调查问卷、匹兹堡睡眠质量指数和医院焦虑抑郁量表问卷对他们与健康相关的生活质量进行评估。69名患者（47.6%）为部分反应者。在8项简短健康调查问卷的5/8个分量表以及心理健康综合评分中，这些患者的得分显著低于反应者。部分反应者的匹兹堡睡眠质量指数和医院焦虑抑郁量表得分，包括焦虑和抑郁得分，显著高于反应者。非糜烂性反流病和双倍质子泵抑制剂剂量是部分反应者的预测因素。尽管接受了质子泵抑制剂治疗，但持续的反流症状在日本胃食管反流病患者中导致了心理健康障碍、睡眠障碍和心理困扰。
