通过ENIGMA精神分裂症研究联盟，阳性症状与颞上回皮质变薄有关。
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.
作者信息
Walton E, Hibar D P, van Erp T G M, Potkin S G, Roiz-Santiañez R, Crespo-Facorro B, Suarez-Pinilla P, Van Haren N E M, de Zwarte S M C, Kahn R S, Cahn W, Doan N T, Jørgensen K N, Gurholt T P, Agartz I, Andreassen O A, Westlye L T, Melle I, Berg A O, Mørch-Johnsen L, Faerden A, Flyckt L, Fatouros-Bergman H, Jönsson E G, Hashimoto R, Yamamori H, Fukunaga M, Preda A, De Rossi P, Piras F, Banaj N, Ciullo V, Spalletta G, Gur R E, Gur R C, Wolf D H, Satterthwaite T D, Beard L M, Sommer I E, Koops S, Gruber O, Richter A, Krämer B, Kelly S, Donohoe G, McDonald C, Cannon D M, Corvin A, Gill M, Di Giorgio A, Bertolino A, Lawrie S, Nickson T, Whalley H C, Neilson E, Calhoun V D, Thompson P M, Turner J A, Ehrlich S
机构信息
Department of Psychology, Georgia State University, Atlanta, GA, USA.
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
出版信息
Acta Psychiatr Scand. 2017 May;135(5):439-447. doi: 10.1111/acps.12718. Epub 2017 Mar 29.
OBJECTIVE
Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.
METHOD
This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.
RESULTS
Positive symptom severity was negatively related to STG thickness in both hemispheres (left: β = -0.052; P = 0.021; right: β = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.
CONCLUSION
Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.
目的
基于颞上回（STG）在听觉处理、语言理解和自我监测中的作用，本研究旨在探讨精神分裂症患者STG皮质厚度与阳性症状严重程度之间的关系。
方法
这项前瞻性荟萃分析纳入了来自全球17个中心的1987例精神分裂症患者的数据，这些数据由ENIGMA精神分裂症工作组提供。使用FreeSurfer从T1加权脑扫描中提取STG厚度测量值。该研究对通过预测左或右STG厚度与阳性症状严重程度评分（统一的SAPS或PANSS阳性评分）的模型在各研究点生成的效应量进行了荟萃分析，同时控制了年龄、性别和研究点。二级模型研究了抗精神病药物治疗、病程、总体疾病严重程度、利手与STG厚度之间的关系。
结果
在对年龄、性别和研究点进行统计学控制后，阳性症状严重程度与两侧半球的STG厚度均呈负相关（左侧：β = -0.052；P = 0.021；右侧：β = -0.073；P = 0.001）。在包括病程、抗精神病药物治疗或利手的模型中，这种效应保持稳定。
结论
我们的研究结果进一步强调了STG在精神分裂症标志性症状中的重要作用。这些发现有助于深入了解精神分裂症中与症状相关的病理生理机制。
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