Grimaldi L M, Roos R P, Devare S G, Robey W G, Casey J M, Gurney M E, Apatoff B R, Lazzarin D
Abbott Laboratories, North Chicago, IL 60064.
J Immunol. 1988 Jul 1;141(1):114-7.
Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently than anti-p24 antibody activity. These antibody activities exhibited restricted heterogeneity of their IEF pattern; this restriction may contribute to the relatively low titers of neutralizing antibody found in AIDS sera. None of the CSF and serum oligoclonal bands showed anti-HIV antibody activity, suggesting that they are directed against opportunistic agents or result from immunodysregulation.
神经系统并发症和脑脊液（CSF）异常在艾滋病中很常见。我们发现，大量有神经系统受累的艾滋病患者通过等电聚焦（IEF）检测，其脑脊液和血清中存在寡克隆IgG带。使用IEF-抗原覆盖技术，抗gp120抗体活性比抗p24抗体活性更频繁地被检测到。这些抗体活性在其IEF图谱中表现出有限的异质性；这种限制可能导致在艾滋病血清中发现的中和抗体滴度相对较低。脑脊液和血清中的寡克隆带均未显示抗HIV抗体活性，这表明它们是针对机会性病原体的，或是免疫失调的结果。
