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使用宽视野对角扫描光学相干断层扫描探头对人鼓膜进行体内三维成像。

In vivo 3D imaging of the human tympanic membrane using a wide-field diagonal-scanning optical coherence tomography probe.

作者信息

Park Kibeom, Cho Nam Hyun, Jang Jeong Hun, Lee Sang Heun, Kim Pilun, Jeon Mansik, Boppart Stephen A, Kim Jeehyun, Jung Woonggyu

出版信息

Appl Opt. 2017 Mar 20;56(9):D115-D119. doi: 10.1364/AO.56.00D115.

DOI:10.1364/AO.56.00D115
PMID:28375378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5508522/
Abstract

A wide-field optical coherence tomography (OCT) probe was developed that adapts a diagonal-scanning scheme for three-dimensional (3D) in vivo imaging of the human tympanic membrane. The probe consists of a relay lens to enhance the lateral scanning range up to 7 mm. Motion artifacts that occur with the use of handheld probes were found to be decreased owing to the diagonal-scanning pattern, which crosses the center of the sample to facilitate entire 3D scans. 3D images could be constructed from a small number of two-dimensional OCT images acquired using the diagonal-scanning technique. To demonstrate the usefulness and performance of the developed system with the handheld probe, in vivo tympanic membranes of humans and animals were imaged in real time.

摘要

开发了一种宽视野光学相干断层扫描（OCT）探头，该探头采用对角扫描方案对人鼓膜进行三维（3D）体内成像。该探头由一个中继透镜组成，可将横向扫描范围扩大至7毫米。由于对角扫描模式穿过样本中心以利于进行完整的3D扫描，因此发现使用手持探头时出现的运动伪影有所减少。利用对角扫描技术采集少量二维OCT图像即可构建3D图像。为了证明所开发的手持探头系统的实用性和性能，对人和动物的体内鼓膜进行了实时成像。