Jiang Si-Qi, Zhang Yu-Bo, Xiao Min, Jiang Lin, Luo Ding, Niu Qian-Wen, Li Yao-Lan, Zhang Xian-Tao, Wang Guo-Cai
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, PR China.
Guangdong Institute of Traditional Chinese Medicine, Guangzhou 510520, PR China; Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Carbohydr Res. 2017 Jun 5;445:1-6. doi: 10.1016/j.carres.2017.03.019. Epub 2017 Mar 30.
Six new cycloartane triterpenoid saponins, thalisides A-F (1-6), along with four known ones (7-10), were isolated from Thalictrum fortunei. The new structures were elucidated by using spectroscopic data (NMR, IR, UV, and MS). Compounds 1-10 were examined for their in vitro cytotoxicity against two human cancer cell lines (HepG2, A549) and antiviral activity against influenza A virus (H1N1) and found to be inactive.
从华东唐松草中分离得到6个新的环阿尔廷烷型三萜皂苷，即唐松草苷A - F（1 - 6），以及4个已知化合物（7 - 10）。通过光谱数据（核磁共振、红外、紫外和质谱）对新结构进行了鉴定。检测了化合物1 - 10对两种人类癌细胞系（HepG2、A549）的体外细胞毒性以及对甲型流感病毒（H1N1）的抗病毒活性，发现它们均无活性。
