Richardson Michael R, Churilla James R
From the Departments of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville.
South Med J. 2017 Apr;110(4):314-317. doi: 10.14423/SMJ.0000000000000632.
To use gender-stratified logistic regression analysis to examine the associations between elevated C-reactive protein (CRP; >3-10 mg/L) and sleep duration.
The study sample included male (n = 5033) and female (n = 4917) adult (20 years old and older) participants in the 2007-2010 National Health and Nutrition Examination Survey. Sleep duration was categorized as short (≤6 hours/day), adequate (7-8 hours/day), or long (≥9 hours/day). Logistic regression models were adjusted for age, race, smoking status, physical activity, and waist circumference.
Analysis revealed significantly ( = 0.0151) higher odds of elevated CRP in men reporting ≤6 hours/day of sleep (odds ratio 1.26, 95% confidence interval 1.05-1.52) when compared with a referent group of men reporting 7 to 8 hours/day of sleep. Similar associations were not revealed in women.
Short sleep duration was significantly associated with elevated serum CRP concentration independent of waist circumference and moderate physical activity in men but not in women.
运用性别分层的逻辑回归分析，研究C反应蛋白（CRP；>3 - 10mg/L）升高与睡眠时间之间的关联。
研究样本包括2007 - 2010年国家健康与营养检查调查中的成年男性（n = 5033）和成年女性（n = 4917）（年龄在20岁及以上）。睡眠时间分为短（≤6小时/天）、适中（7 - 8小时/天）或长（≥9小时/天）。逻辑回归模型对年龄、种族、吸烟状况、身体活动和腰围进行了校正。
分析显示，与报告睡眠时间为7至8小时/天的男性参照组相比，报告睡眠时间≤6小时/天的男性CRP升高的几率显著更高（P = 0.0151）（比值比1.26，95%置信区间1.05 - 1.52）。在女性中未发现类似关联。
睡眠时间短与男性血清CRP浓度升高显著相关，且不受腰围和适度身体活动的影响，但在女性中并非如此。
