Department of Breast Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
Department of Urology Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China.
Sci Rep. 2017 Apr 4;7(1):599. doi: 10.1038/s41598-017-00635-5.
We aimed to conduct a meta-analysis investigating the association between consumption of vegetables and fruits and breast cancer survival. A comprehensive search of the PubMed and EMBASE was performed from the inception to September 30, 2016. The summary hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a random effects model. Ten studies, with a total of 31,210 breast cancer cases, were included in the meta-analysis. The summary HRs (95% CIs) of overall survival (highest vs. lowest) were 1.08 (0.88-1.33; I = 41.1%) for pre-diagnostic intake of vegetables and fruits combined, 0.96 (0.71-1.30; I = 48.4%) for vegetables alone, and 0.83 (0.67-1.02; I = 0) for fruit alone. No significant risk associations of overall survival were found for post-diagnostic intake of vegetables and fruits. Line dose-response analyses indicated the likely results for both pre- and post- diagnostic dietary intake. No significant association was found between intake of vegetables and fruits and breast cancer-specific mortality. In addition, intake of cruciferous vegetables was not associated with death from breast cancer. Our findings indicated a borderline inverse association between pre-diagnostic intake of fruit and overall survival of breast cancer, whereas intake of vegetables was not associated with survival.
我们旨在进行一项荟萃分析，研究蔬菜和水果的消费与乳腺癌生存之间的关系。从 2016 年 9 月 30 日开始，我们对 PubMed 和 EMBASE 进行了全面搜索。使用随机效应模型估计了汇总风险比 (HR) 和 95%置信区间 (CI)。共有 10 项研究，总计 31210 例乳腺癌病例，纳入了荟萃分析。总体生存 (最高与最低) 的汇总 HR (95%CI) 为蔬菜和水果联合摄入的 1.08 (0.88-1.33; I = 41.1%)，蔬菜单独摄入的 0.96 (0.71-1.30; I = 48.4%)，水果单独摄入的 0.83 (0.67-1.02; I = 0)。诊断后蔬菜和水果的摄入与总体生存无显著风险关联。线性剂量反应分析表明了诊断前后饮食摄入的可能结果。蔬菜和水果的摄入与乳腺癌特异性死亡率之间没有显著的关联。此外，十字花科蔬菜的摄入与乳腺癌死亡无关。我们的研究结果表明，在诊断前摄入水果与乳腺癌的总体生存之间存在边缘负相关，而摄入蔬菜与生存无关。
