Fu Ying, Li Hui, Hao Xishan
Department of Gastrointestinal Cancer Biology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China.
Tumour Biol. 2017 Apr;39(4):1010428317697577. doi: 10.1177/1010428317697577.
Gastric cancer is a leading cause of cancer-related mortality worldwide. Cancer stem cells are the source of tumor recurrence and metastasis. Self-renewal is a marker of cancer stem cells and also the basis of long-lasting survival and tumor progression. Although the mechanism of gastric cancer stem cell self-renewal is not clear, there are several signaling pathways and environmental factors known to be involved. This mini review describes recent developments in the self-renewal signaling pathway of gastric cancer stem cell research. Advancements made in this field of research will likely support the development of novel therapeutic strategies for gastric cancer.
胃癌是全球癌症相关死亡的主要原因。癌症干细胞是肿瘤复发和转移的根源。自我更新是癌症干细胞的一个标志，也是长期存活和肿瘤进展的基础。尽管胃癌干细胞自我更新的机制尚不清楚，但已知有几种信号通路和环境因素与之相关。这篇综述描述了胃癌干细胞研究中自我更新信号通路的最新进展。该研究领域取得的进展可能会支持胃癌新治疗策略的开发。
