Rott O, Kröger M, Müller H, Hobom G
Institut für Mikrobiologie und Molekularbiologie, Justus-Liebig-Uniersität Giessen, Federal Republic of Germany.
Virology. 1988 Jul;165(1):74-86. doi: 10.1016/0042-6822(88)90660-5.
Budgerigar fledgling disease virus (BFDV) represents the first avian member of the Polyomavirus family. In contrast to mammalian polyomaviruses BFDV exhibits unique biological properties, in particular it is able to cause an acute disease with distinct organ manifestations in affected birds. Here we present the complete nucleotide sequence of the BFDV genome, consisting of 4980 bp. When compared to published nucleotide sequences of other polyomaviruses, the BFDV genome exposes a number of very similar structural features, and undoubtedly qualifies as a member of that family of viruses. The most important differences include a large T antigen remarkably reduced in size, and an origin of replication region with fundamental deviations from the origin structure of all other polyomaviruses. The specific characteristics of the BFDV genome may be used to place this virus into a distinct subgroup within the Polyomavirus family and may give a clue to the elucidation of its extraordinary biological properties.
虎皮鹦鹉雏鸟病病毒（BFDV）是多瘤病毒科的首个禽类成员。与哺乳动物多瘤病毒相比，BFDV具有独特的生物学特性，尤其是它能够在受感染的鸟类中引发具有明显器官表现的急性疾病。在此，我们展示了由4980个碱基对组成的BFDV基因组的完整核苷酸序列。与其他多瘤病毒已公布的核苷酸序列相比，BFDV基因组呈现出许多非常相似的结构特征，无疑属于该病毒家族的成员。最重要的差异包括大小显著减小的大T抗原，以及与所有其他多瘤病毒的起源结构存在根本偏差的复制起点区域。BFDV基因组的特定特征可用于将该病毒归入多瘤病毒科内的一个独特亚组，并可能为阐明其非凡的生物学特性提供线索。
