Oh Shin Ju, Ihm Chun Gyoo, Lee Tae Won, Kim Jin Sug, Kim Da Rae, Park Eun Ji, Jung Su Woong, Lee Ji-Hoon, Heo Sung Hyuk, Jeong Kyung Hwan
Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Kidney Res Clin Pract. 2017 Mar;36(1):100-104. doi: 10.23876/j.krcp.2017.36.1.100. Epub 2017 Mar 31.
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a potential cause of hyponatremia of the central nervous system (CNS). Although SIADH has been reported to be associated with many other central nervous disorders, its association with neuromyelitis optica (NMO) or NMO spectrum disorders are rare. NMO is a demyelinating disorder characterized by optic neuritis and transverse myelitis. Aquaporin-4 (AQP4), which is the target antigen for a NMO autoantibody, is the predominant CNS water channel. However, some NMO patients show seronegative AQP4 antibody results. The spectrum of NMO has been changed, and new findings about the disease have been reported. Here, we report a case of seronegative NMO spectrum disorder associated with SIADH.
抗利尿激素分泌异常综合征（SIADH）是中枢神经系统（CNS）低钠血症的一个潜在原因。尽管已有报道称SIADH与许多其他中枢神经系统疾病有关，但其与视神经脊髓炎（NMO）或NMO谱系障碍的关联却很罕见。NMO是一种以视神经炎和横贯性脊髓炎为特征的脱髓鞘疾病。水通道蛋白4（AQP4）是NMO自身抗体的靶抗原，是中枢神经系统主要的水通道。然而，一些NMO患者的AQP4抗体检测结果为阴性。NMO的谱系已经发生了变化，关于该疾病也有了新的报道。在此，我们报告一例与SIADH相关的血清阴性NMO谱系障碍病例。
