Fisher M, Levine P H, Weiner B H, Vaudreuil C H, Natale A, Johnson M H, Hoogasian J J
Department of Neurology, Worcester Memorial Hospital, Massachusetts.
Inflammation. 1988 Apr;12(2):123-31. doi: 10.1007/BF00916395.
Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active multiple sclerosis demyelination and are assumed to be involved in the demyelinating process. These inflammatory cells produce a variety of toxic oxygen metabolites which can mediate host tissue destruction. We measured production of two oxygen metabolites by monocytes and polymorphonuclear leukocytes in MS patients and controls. Stimulated monocytes produced significantly more hydrogen peroxide, superoxide, and chemiluminescence in the MS group than controls. The polymorphonuclear leukocyte, an inflammatory cell that appears to contribute little to MS demyelination, did not demonstrate increased production of toxic oxygen metabolites in the MS patients as compared to controls. These results suggest that blood monocytes in MS patients are primed to produce increased amounts of cytotoxic oxygen metabolites when exposed to inflammatory stimuli.
富含脂质的巨噬细胞主要来源于血液单核细胞，存在于活动性多发性硬化脱髓鞘部位，并被认为参与了脱髓鞘过程。这些炎性细胞产生多种有毒的氧代谢产物，可介导宿主组织破坏。我们检测了多发性硬化患者和对照组中单核细胞和多形核白细胞产生的两种氧代谢产物。与对照组相比，多发性硬化组中受刺激的单核细胞产生的过氧化氢、超氧化物和化学发光明显更多。多形核白细胞是一种似乎对多发性硬化脱髓鞘作用不大的炎性细胞，与对照组相比，多发性硬化患者中其有毒氧代谢产物的产生并未增加。这些结果表明，多发性硬化患者的血液单核细胞在受到炎性刺激时会被激活，产生更多的细胞毒性氧代谢产物。
