Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, 37 S. P. Mukherjee Road, Kolkata 700 026, West Bengal, India.
Clinical and Translational Research, Chittaranjan National Cancer Institute, Kolkata 700 026, West Bengal, India.
Semin Cancer Biol. 2017 Oct;46:33-54. doi: 10.1016/j.semcancer.2017.04.001. Epub 2017 Apr 7.
The National Cancer Institute of the United States had projected breast cancer as one of the topmost prevalent malignancies of 2016. It was estimated that in 2016, 246,660 new cases of invasive breast cancer were expected to be diagnosed in women in the US, along with 61,000 new cases of non-invasive (in situ) breast cancer. The heterogeneity of breast cancer accounts for its differential molecular subtyping. Recent incorporation of high throughput approaches helps early prognosis of breast cancer, but recurrence of the disease stands to be one of the most daunting fact behind non-availability of third line treatment. At this point of crisis, application of chemopreventive measures could possibly resolve the enigma of breast cancer. The world class beverage tea has proven its efficacy in ameliorating various genetic and epigenetic anomalies in breast cancer. Tea phytoconstituents are known to modulate myriad molecular events which include prominent regulators of intracellular signaling, such as phosphatidylinositide 3-kinase/protein kinase B/nuclear factor-κB, epidermal growth factor receptor, vascular endothelial growth factor, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein in the development and progression of breast carcinoma. This review aims to encompass the detailed modulatory roles of tea phytochemicals, their analogs and nanoformulations against mammary carcinoma and the probability of using tea in therapeutic management of breast cancer. Finally, current limitations, challenges and future directions of tea and breast cancer research are also critically discussed.
美国国家癌症研究所曾预测乳腺癌是 2016 年最常见的恶性肿瘤之一。据估计，2016 年美国将有 246660 名女性被诊断患有浸润性乳腺癌，61000 名女性被诊断患有非浸润性（原位）乳腺癌。乳腺癌的异质性导致了其不同的分子分型。最近高通量方法的应用有助于乳腺癌的早期预后，但疾病的复发是由于缺乏三线治疗而成为最令人畏惧的事实之一。在这一危机时刻，应用化学预防措施可能有助于解决乳腺癌的谜团。世界级的饮料茶已被证明能改善乳腺癌中的各种遗传和表观遗传异常。茶植物成分被认为能调节多种分子事件，包括细胞内信号的主要调节剂，如磷脂酰肌醇 3-激酶/蛋白激酶 B/核因子-κB、表皮生长因子受体、血管内皮生长因子、B 细胞淋巴瘤 2（Bcl-2）和 Bcl-2 相关 X 蛋白，这些都是乳腺癌发生和发展的重要调节因子。本综述旨在综述茶植物化学物质、其类似物和纳米制剂对乳腺癌的详细调节作用，以及茶在乳腺癌治疗管理中的应用潜力。最后，还批判性地讨论了茶和乳腺癌研究的当前局限性、挑战和未来方向。
