Department of Plant Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Department of Plant Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Eur J Pharmacol. 2018 May 15;827:125-148. doi: 10.1016/j.ejphar.2018.03.007. Epub 2018 Mar 10.
Breast cancer (BC) is a devastating disease in female around the world causing significant health care burden in both developed and developing countries. In many cases BC has shown resistance to chemotherapy, radiation and hormonal therapy. Development of new, cost effective, affordable treatment method is the need of hour. Chemical compounds isolated from plants are often biologically active and is attracting the attention of scientific community. Different in vitro and in vivo studies have shown a potential role in reducing the risk of cancer metastasis. Large number of phytochemicals are considered to regulate several molecular and metabolic processes like cell cycle regulation, apoptosis activation, angiogenesis and metastatic suppression that can hinders cancer progression. An extensive review of literature has been conducted to underline the key phytochemicals and their mechanism of action. This review article has discussed in detail the regulatory roles of phytochemicals, their analogs and nanoformulations and the probability of using phytochemicals in therapeutic management of BC. Finally, current limitations, challenges and future perspectives of these phytochemicals are also critically discussed.
乳腺癌（BC）是全球女性的一种毁灭性疾病，在发达国家和发展中国家都造成了巨大的医疗负担。在许多情况下，BC 已经显示出对化疗、放疗和激素治疗的耐药性。开发新的、具有成本效益的、负担得起的治疗方法是当务之急。从植物中分离出的化合物通常具有生物活性，这引起了科学界的关注。大量的植物化学物质被认为可以调节细胞周期调节、细胞凋亡激活、血管生成和转移抑制等多个分子和代谢过程，从而阻碍癌症的进展。对文献进行了广泛的综述，以强调关键的植物化学物质及其作用机制。本文详细讨论了植物化学物质、它们的类似物和纳米制剂的调节作用，以及在乳腺癌治疗管理中使用植物化学物质的可能性。最后，还批判性地讨论了这些植物化学物质的当前局限性、挑战和未来展望。
