Watson Alan M, Klimstra William B
Center for Vaccine Research, Departments of Microbiology and Molecular Genetics, and Immunology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.
Viruses. 2017 Apr 11;9(4):77. doi: 10.3390/v9040077.
The 17D line of yellow fever virus vaccines is among the most effective vaccines ever created. The humoral and cellular immunity elicited by 17D has been well characterized in humans. Neutralizing antibodies have long been known to provide protection against challenge with a wild-type virus. However, a well characterized T cell immune response that is robust, long-lived and polyfunctional is also elicited by 17D. It remains unclear whether this arm of immunity is protective following challenge with a wild-type virus. Here we introduce the 17D line of yellow fever virus vaccines, describe the current state of knowledge regarding the immunity directed towards the vaccines in humans and conclude with a discussion of animal models that are useful for evaluating T cell-mediated immune protection to yellow fever virus.
黄热病病毒疫苗17D株是有史以来最有效的疫苗之一。17D株引发的体液免疫和细胞免疫在人体中已有充分的特征描述。长期以来，人们已知中和抗体可提供针对野生型病毒攻击的保护作用。然而，17D株还能引发一种特征明确、强大、持久且多功能的T细胞免疫反应。尚不清楚在受到野生型病毒攻击后，这种免疫分支是否具有保护作用。在此，我们介绍黄热病病毒疫苗17D株，描述目前关于人体针对该疫苗的免疫的知识现状，并以对用于评估黄热病病毒T细胞介导的免疫保护的动物模型的讨论作为结尾。
