针对黄热病病毒的T细胞介导免疫及有用的动物模型
T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models.
作者信息
Watson Alan M, Klimstra William B
机构信息
Center for Vaccine Research, Departments of Microbiology and Molecular Genetics, and Immunology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.
出版信息
Viruses. 2017 Apr 11;9(4):77. doi: 10.3390/v9040077.
Abstract
The 17D line of yellow fever virus vaccines is among the most effective vaccines ever created. The humoral and cellular immunity elicited by 17D has been well characterized in humans. Neutralizing antibodies have long been known to provide protection against challenge with a wild-type virus. However, a well characterized T cell immune response that is robust, long-lived and polyfunctional is also elicited by 17D. It remains unclear whether this arm of immunity is protective following challenge with a wild-type virus. Here we introduce the 17D line of yellow fever virus vaccines, describe the current state of knowledge regarding the immunity directed towards the vaccines in humans and conclude with a discussion of animal models that are useful for evaluating T cell-mediated immune protection to yellow fever virus.
摘要
黄热病病毒疫苗17D株是有史以来最有效的疫苗之一。17D株引发的体液免疫和细胞免疫在人体中已有充分的特征描述。长期以来，人们已知中和抗体可提供针对野生型病毒攻击的保护作用。然而，17D株还能引发一种特征明确、强大、持久且多功能的T细胞免疫反应。尚不清楚在受到野生型病毒攻击后，这种免疫分支是否具有保护作用。在此，我们介绍黄热病病毒疫苗17D株，描述目前关于人体针对该疫苗的免疫的知识现状，并以对用于评估黄热病病毒T细胞介导的免疫保护的动物模型的讨论作为结尾。
相似文献
1
T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models.针对黄热病病毒的T细胞介导免疫及有用的动物模型
Viruses. 2017 Apr 11;9(4):77. doi: 10.3390/v9040077.
2
The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells.17D - 204疫苗株诱导的针对强毒性黄热病毒的保护作用是由体液免疫和CD4 + 而非CD8 + T细胞介导的。
PLoS Pathog. 2016 Jul 27;12(7):e1005786. doi: 10.1371/journal.ppat.1005786. eCollection 2016 Jul.
3
Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection .III型干扰素介导的信号传导对于控制减毒活黄热病病毒感染至关重要。
mBio. 2017 Aug 15;8(4):e00819-17. doi: 10.1128/mBio.00819-17.
4
Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice.比较黄热病 17D 疫苗在小鼠中的免疫原性和保护效力。
Emerg Microbes Infect. 2021 Dec;10(1):2279-2290. doi: 10.1080/22221751.2021.2008772.
5
A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice.嵌合黄热病-寨卡病毒疫苗候选物可完全保护小鼠免受黄热病病毒感染。
Emerg Microbes Infect. 2020 Mar 2;9(1):520-533. doi: 10.1080/22221751.2020.1730709. eCollection 2020.
6
A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies.一种嵌合日本脑炎疫苗可预防致死性黄热病病毒感染而不诱导中和抗体。
mBio. 2020 Apr 7;11(2):e02494-19. doi: 10.1128/mBio.02494-19.
7
Activation and Kinetics of Circulating T Follicular Helper Cells, Specific Plasmablast Response, and Development of Neutralizing Antibodies following Yellow Fever Virus Vaccination.黄热病毒疫苗接种后循环滤泡辅助 T 细胞的激活和动力学、特异性浆母细胞应答以及中和抗体的产生。
J Immunol. 2021 Aug 15;207(4):1033-1043. doi: 10.4049/jimmunol.2001381. Epub 2021 Jul 28.
8
Molecular and immunological characterization of a DNA-launched yellow fever virus 17D infectious clone.一种DNA启动的黄热病毒17D感染性克隆的分子和免疫学特征
J Gen Virol. 2015 Apr;96(Pt 4):804-814. doi: 10.1099/jgv.0.000026. Epub 2014 Dec 16.
9
Live attenuated chimeric yellow fever dengue type 2 (ChimeriVax-DEN2) vaccine: Phase I clinical trial for safety and immunogenicity: effect of yellow fever pre-immunity in induction of cross neutralizing antibody responses to all 4 dengue serotypes.减毒活嵌合黄热2型登革热疫苗（ChimeriVax-DEN2）：安全性和免疫原性的I期临床试验：黄热预免疫对诱导针对所有4种登革热血清型的交叉中和抗体反应的影响。
Hum Vaccin. 2006 Mar-Apr;2(2):60-7. doi: 10.4161/hv.2.2.2555. Epub 2006 Mar 15.
10
Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses.黄热病病毒的疫苗株和野生型毒株采用不同的进入机制，并以不同方式刺激抗病毒免疫反应。
mBio. 2016 Feb 9;7(1):e01956-15. doi: 10.1128/mBio.01956-15.
引用本文的文献
1
Induction of systemic and mucosal immune response against Zika virus by vaccination with non-infectious chimeric VLPs.通过接种非感染性嵌合病毒样颗粒诱导针对寨卡病毒的全身和黏膜免疫反应。
Sci Rep. 2025 Jul 10;15(1):24834. doi: 10.1038/s41598-025-07059-6.
2
Yellow Fever: Global Impact, Epidemiology, Pathogenesis, and Integrated Prevention Approaches.黄热病：全球影响、流行病学、发病机制及综合预防方法
Infez Med. 2024 Dec 1;32(4):434-450. doi: 10.53854/liim-3204-3. eCollection 2024.
3
Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections.利用T细胞加强针对病毒感染的疫苗研发。
Vaccines (Basel). 2024 Apr 29;12(5):478. doi: 10.3390/vaccines12050478.
4
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine design.疫苗设计的下一个前沿：将保护的免疫相关因素融入合理的疫苗设计中。
Curr Opin Immunol. 2022 Oct;78:102234. doi: 10.1016/j.coi.2022.102234. Epub 2022 Aug 13.
5
Yellow fever vaccination in Brazil: Short-term safety and immunogenicity in juvenile autoimmune rheumatic diseases.巴西的黄热病疫苗接种：青少年自身免疫性风湿病的短期安全性和免疫原性
Vaccine X. 2021 Dec 10;10:100131. doi: 10.1016/j.jvacx.2021.100131. eCollection 2022 Apr.
6
A Yellow Fever 17D Virus Replicon-Based Vaccine Platform for Emerging Coronaviruses.一种基于黄热病17D病毒复制子的新兴冠状病毒疫苗平台。
Vaccines (Basel). 2021 Dec 16;9(12):1492. doi: 10.3390/vaccines9121492.
7
Activation and Kinetics of Circulating T Follicular Helper Cells, Specific Plasmablast Response, and Development of Neutralizing Antibodies following Yellow Fever Virus Vaccination.黄热病毒疫苗接种后循环滤泡辅助 T 细胞的激活和动力学、特异性浆母细胞应答以及中和抗体的产生。
J Immunol. 2021 Aug 15;207(4):1033-1043. doi: 10.4049/jimmunol.2001381. Epub 2021 Jul 28.
8
What Constitutes Protective Immunity Following Yellow Fever Vaccination?黄热病疫苗接种后产生的保护性免疫由哪些因素构成？
Vaccines (Basel). 2021 Jun 18;9(6):671. doi: 10.3390/vaccines9060671.
9
Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses.黄热病病毒疫苗接种：阐明强大的人类免疫反应的典范模型。
Hum Vaccin Immunother. 2021 Aug 3;17(8):2471-2481. doi: 10.1080/21645515.2021.1891752. Epub 2021 Apr 28.
10
Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A.黄热病疫苗接种后有效免疫应答的激活与遗传背景和 IFN-γ 及 CLEC5A 的早期反应有关。
Viruses. 2021 Jan 12;13(1):96. doi: 10.3390/v13010096.
本文引用的文献
1
Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review.I 型干扰素信号在免疫和炎症中的调控：全面综述。
J Autoimmun. 2017 Sep;83:1-11. doi: 10.1016/j.jaut.2017.03.008. Epub 2017 Mar 19.
2
Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome.单细胞追踪黄病毒 RNA 揭示了与免疫系统的种特异性相互作用，从而决定疾病的结果。
Nat Commun. 2017 Mar 14;8:14781. doi: 10.1038/ncomms14781.
3
The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells.17D - 204疫苗株诱导的针对强毒性黄热病毒的保护作用是由体液免疫和CD4 + 而非CD8 + T细胞介导的。
PLoS Pathog. 2016 Jul 27;12(7):e1005786. doi: 10.1371/journal.ppat.1005786. eCollection 2016 Jul.
4
Yellow fever cases in Asia: primed for an epidemic.亚洲的黄热病病例：为流行做好准备。
Int J Infect Dis. 2016 Jul;48:98-103. doi: 10.1016/j.ijid.2016.04.025. Epub 2016 May 6.
5
On the Seasonal Occurrence and Abundance of the Zika Virus Vector Mosquito Aedes Aegypti in the Contiguous United States.关于寨卡病毒传播媒介埃及伊蚊在美国本土的季节性出现情况及数量
PLoS Curr. 2016 Mar 16;8:ecurrents.outbreaks.50dfc7f46798675fc63e7d7da563da76. doi: 10.1371/currents.outbreaks.50dfc7f46798675fc63e7d7da563da76.
6
A Single 17D Yellow Fever Vaccination Provides Lifelong Immunity; Characterization of Yellow-Fever-Specific Neutralizing Antibody and T-Cell Responses after Vaccination.单次17D黄热病疫苗接种可提供终身免疫；接种疫苗后黄热病特异性中和抗体及T细胞反应的特征分析
PLoS One. 2016 Mar 15;11(3):e0149871. doi: 10.1371/journal.pone.0149871. eCollection 2016.
7
Vaccination with Replication Deficient Adenovectors Encoding YF-17D Antigens Induces Long-Lasting Protection from Severe Yellow Fever Virus Infection in Mice.用编码YF-17D抗原的复制缺陷型腺病毒载体进行疫苗接种可诱导小鼠对严重黄热病病毒感染产生持久保护。
PLoS Negl Trop Dis. 2016 Feb 17;10(2):e0004464. doi: 10.1371/journal.pntd.0004464. eCollection 2016 Feb.
8
Long-lasting stem cell-like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination.黄热病疫苗接种后可诱导持久的具有初始样表型的干细胞样记忆 CD8+T 细胞。
Sci Transl Med. 2015 Apr 8;7(282):282ra48. doi: 10.1126/scitranslmed.aaa3700.
9
Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons.病毒进入途径决定了人浆细胞样树突状细胞如何产生 I 型干扰素。
Sci Signal. 2015 Mar 3;8(366):ra25. doi: 10.1126/scisignal.aaa1552.
10
Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination.初始病毒载量决定了人类CD8 T细胞对黄热病疫苗接种的反应程度。
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3050-5. doi: 10.1073/pnas.1500475112. Epub 2015 Feb 23.
Zotero 插件