Herrera Bobby Brooke, Chang Charlotte A, Hamel Donald J, Mboup Souleymane, Ndiaye Daouda, Imade Godwin, Okpokwu Jonathan, Agbaji Oche, Bei Amy K, Kanki Phyllis J
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Department of Parasitology and Mycology, Cheikh Anta Diop University and Le Dantec Hospital, and.
J Infect Dis. 2017 May 15;215(10):1546-1550. doi: 10.1093/infdis/jix182.
First identified in 1947 in Uganda, Zika virus (ZIKV) has remained largely unstudied until the recent outbreak in Latin America. This study aimed to measure the prevalence of ZIKV in febrile patients in Senegal and Nigeria in samples collected from 1992 to 2016. The seroprevalence of ZIKV was 6.2% based on ZIKV immunoglobulin M and negative for dengue reactivity. ZIKV envelope was amplified from 4 samples. Phylogenetic analysis showed that the ZIKVs belonged to the African lineage, grouping with either the Nigerian or MR766 sublineages. This study provides evidence that ZIKV has been silently circulating in West Africa for 2 decades.
寨卡病毒（ZIKV）于1947年在乌干达首次被发现，直到最近在拉丁美洲爆发疫情之前，人们对其研究甚少。本研究旨在测定1992年至2016年期间在塞内加尔和尼日利亚采集的发热患者样本中寨卡病毒的流行率。基于寨卡病毒免疫球蛋白M检测，寨卡病毒血清阳性率为6.2%，登革热反应呈阴性。从4份样本中扩增出了寨卡病毒包膜。系统发育分析表明，这些寨卡病毒属于非洲谱系，与尼日利亚或MR766亚谱系归为一类。本研究提供了证据，证明寨卡病毒已在西非悄然传播了20年。
