缅甸寨卡病毒感染的检测。
Detection of Zika Virus Infection in Myanmar.
机构信息
Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Virology Research Division, Department of Medical Research, Pyin Oo Lwin, Myanmar.
出版信息
Am J Trop Med Hyg. 2018 Mar;98(3):868-871. doi: 10.4269/ajtmh.17-0708. Epub 2018 Jan 18.
Zika virus (ZIKV), an emerging mosquito-borne flavivirus, causes a dengue-like infection that has recently caught global attention. The infection, which also includes some birth defects, has been documented in the Americas, Pacific Islands, and some parts of Africa and Asia. There are no published reports on local ZIKV transmission in Myanmar. In this study, a total of 462 serum samples from patients and asymptomatic persons were collected in Myanmar from 2004 to 2017. They were analyzed for ZIKV infection by immunoglobulin M capture enzyme-linked immunosorbent assay (ELISA), immunoglobulin G indirect ELISA, neutralization test, real-time polymerase chain reaction (PCR), and conventional PCR. Our study confirmed ZIKV infection in 4.9% of patients with clinical dengue symptoms and in 8.6% of persons who were asymptomatic. This is the first report on ZIKV infection in Myanmar and it suggests the occurrence of ZIKV infection in two geographically distinct sites in this country since at least 2006.
Zika 病毒（ZIKV）是一种新兴的蚊媒黄病毒，可引起类似于登革热的感染，最近引起了全球关注。这种感染还包括一些出生缺陷，已在美洲、太平洋岛屿以及非洲和亚洲的一些地区有记录。缅甸尚无本地 ZIKV 传播的报道。在这项研究中，2004 年至 2017 年间，从缅甸的患者和无症状者中总共采集了 462 份血清样本。通过免疫球蛋白 M 捕获酶联免疫吸附试验（ELISA）、免疫球蛋白 G 间接 ELISA、中和试验、实时聚合酶链反应（PCR）和常规 PCR 对这些样本进行了 ZIKV 感染分析。我们的研究在有临床登革热症状的患者中确认了 4.9%的 ZIKV 感染，在无症状者中确认了 8.6%的 ZIKV 感染。这是缅甸首例关于 ZIKV 感染的报告，表明自 2006 年以来，该国至少有两个地理位置不同的地区发生了 ZIKV 感染。
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