Centre for Systems Chemistry, Stratingh Institute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
J Am Chem Soc. 2017 May 3;139(17):6234-6241. doi: 10.1021/jacs.7b01814. Epub 2017 Apr 24.
With the advent of reversible covalent chemistry the study of the interplay between covalent bond formation and noncovalent interactions has become increasingly relevant. Here we report that the interplay between reversible disulfide chemistry and self-assembly can give rise either to molecular diversity, i.e., the emergence of a unprecedentedly large range of macrocycles or to molecular specificity, i.e., the autocatalytic emergence of a single species. The two phenomena are the result of two different modes of self-assembly, demonstrating that control over self-assembly pathways can enable control over covalent bond formation.
随着可逆共价化学的出现，研究共价键形成和非共价相互作用之间的相互作用变得越来越重要。在这里，我们报告说，可逆二硫键化学和自组装之间的相互作用既可以产生分子多样性，即出现前所未有的大环范围，也可以产生分子特异性，即单一物种的自动催化出现。这两种现象是两种不同自组装模式的结果，表明对自组装途径的控制可以实现对共价键形成的控制。
