Kocasarac Can, Yigit Yavuz, Sengul Erkan, Sakalar Yildirim Beyazit
Department of Ophthalmology, Derince Training and Research Hospital, Derince, Kocaeli, Turkey.
Department of Emergency, Derince Training and Research Hospital, Derince, Kocaeli, Turkey.
Int Ophthalmol. 2018 Apr;38(2):721-726. doi: 10.1007/s10792-017-0523-5. Epub 2017 Apr 11.
To assess changes in choroidal thickness (CT) in diabetes patients with and without diabetic nephropathy using enhanced depth imaging spectral domain optical coherence tomography (EDI-OCT).
Thirty-five type 2 diabetes patients with a diagnosis of diabetic nephropathy (DNP) in nephrology department and 35 type 2 diabetes patients without nephropathy (non-DNP) were included in our prospective study consecutively. The control group comprised 34 healthy individuals. CT measurements were recorded under the fovea and at 1500 µm from the foveal center in the nasal and temporal sides. The study parameters also included age, refractive error, axial length, intraocular pressure, HbA1c, glomerular filtration rate and proteinuria amount.
The subfoveal, temporal and nasal choroidal thickness was noted to be thinner in patients with DNP compared with non-DNP and normal subjects (p < 0.05). However, CT measurements did not show any difference between the healthy and non-DNP group.
CT decreases significantly in diabetic patients when diabetic nephropathy accompanies diabetes mellitus.
使用增强深度成像光谱域光学相干断层扫描（EDI-OCT）评估合并和未合并糖尿病肾病的糖尿病患者脉络膜厚度（CT）的变化。
我们的前瞻性研究连续纳入了35例在肾内科诊断为糖尿病肾病（DNP）的2型糖尿病患者和35例无肾病的2型糖尿病患者（非DNP）。对照组包括34名健康个体。在中央凹以及距中央凹中心鼻侧和颞侧1500 µm处记录CT测量值。研究参数还包括年龄、屈光不正、眼轴长度、眼压、糖化血红蛋白、肾小球滤过率和蛋白尿总量。
与非DNP患者和正常受试者相比，DNP患者的中央凹下、颞侧和鼻侧脉络膜厚度更薄（p < 0.05）。然而，CT测量在健康组和非DNP组之间未显示出任何差异。
当糖尿病合并糖尿病肾病时，糖尿病患者的CT显著降低。
