Torabi Hamidreza, Saberi Isfeedvajani Mohsen, Ramezani Majid, Daryabari Seyed-Hashem
Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Medicine, Quran and Hadith Research Center and Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2019 Jul 18;14(3):285-290. doi: 10.18502/jovr.v14i3.4784. eCollection 2019 Jul-Sep.
The aim of this study was to assess the correlation of hemoglobin A1c (HbA1c) levels with choroidal thickness in patients with type 2 diabetes mellitus (DM) using spectral domain optical coherence tomography (SD-OCT).
In this prospective case series, 180 eyes from 90 patients with type 2 DM were classified into three study groups based on HbA1c values: group 1 included patients with good glycemic control (HbA1c 7%), group 2 included patients with moderate glycemic control (HbA1c between 7% and 8%), and group 3 included patients with poor glycemic control (HbA1c 8%). Additionally, 50 eyes from 25 non-diabetic subjects were enrolled to group 4 as a control group. Sub-foveal, nasal, and temporal choroidal thickness were measured and compared.
Mean central, nasal, and temporal choroidal thicknesses in diabetic patients (247.80, 238.63, and 239.30 m) were significantly less than non-diabetic healthy subjects (277.56, 262.92, and 266.32 m). Additionally, mean central, nasal, and temporal choroidal thickness values in group 4 (277.56, 262.92, and 266.32 m) were significantly greater than the corresponding values in group 2 (248.34, 237.55, and 236.45 m) and group 3 (239.81, 234.62, and 233.94 m), but was not significantly different from corresponding values in group 1 (259.46, 246.12, and 251.00 m).
HbA1c values have a significant correlation with choroidal thickness in diabetic patients, and better glycemic control with HbA1c 7% may prevent choroidal thinning.
本研究旨在利用频域光学相干断层扫描（SD - OCT）评估2型糖尿病（DM）患者糖化血红蛋白（HbA1c）水平与脉络膜厚度之间的相关性。
在这个前瞻性病例系列研究中，90例2型糖尿病患者的180只眼睛根据HbA1c值被分为三个研究组：第1组包括血糖控制良好的患者（HbA1c＜7%），第2组包括血糖控制中等的患者（HbA1c在7%至8%之间），第3组包括血糖控制差的患者（HbA1c＞8%）。此外，25名非糖尿病受试者的50只眼睛被纳入第4组作为对照组。测量并比较黄斑中心凹下、鼻侧和颞侧的脉络膜厚度。
糖尿病患者的平均中心、鼻侧和颞侧脉络膜厚度（分别为247.80、238.63和239.30μm）显著低于非糖尿病健康受试者（分别为277.56、262.92和266.32μm）。此外，第4组的平均中心、鼻侧和颞侧脉络膜厚度值（分别为277.56、262.92和266.32μm）显著大于第2组（分别为248.34、237.55和236.45μm）和第3组（分别为239.81、234.62和233.94μm）的相应值，但与第1组（分别为259.46、246.12和251.00μm）的相应值无显著差异。
HbA1c值与糖尿病患者的脉络膜厚度显著相关，HbA1c＜7%的更好血糖控制可能预防脉络膜变薄。
