Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3JR Edinburgh, Scotland, UK.
J Cell Biol. 2012 Nov 26;199(5):719-21. doi: 10.1083/jcb.201210135.
Before the final step of cytokinesis, termed abscission, dividing cells need to ensure that the cleavage plane is clear of chromatin. In this issue, Kotadia et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201208041) show that in Drosophila melanogaster, larval neuroblasts elongate to allow segregation of extra-long chromatids and clearance of the midzone, thereby avoiding cytokinesis failure and aneuploidy.
在胞质分裂的最后一步,即分离(abscission)之前,分裂细胞需要确保分裂面不含染色质。在本期杂志中,Kotadia 等人(2012. J. Cell Biol. http://dx.doi.org/jcb.201208041)表明,在黑腹果蝇中,幼虫神经母细胞伸长,以便分离超长的染色单体并清除中部区,从而避免胞质分裂失败和非整倍体。