State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.
University of Science and Technology of China , Hefei, Anhui 230029, P. R. China.
ACS Nano. 2017 May 23;11(5):4651-4659. doi: 10.1021/acsnano.7b00343. Epub 2017 Apr 17.
Silver nanoparticles (AgNPs) have been used as a broad-spectrum antimicrobial agent, whose toxicity originates from the localized release of Ag ions. However, the residual AgNPs core could generate potential risk to humans and waste of noble metals. Herein, we infused the cysteine-modified molybdenum disulfide with minimum Ag ions and coated with a layer of cationic polyelectrolyte to construct an efficient and benign antimicrobial depot. The system exhibited much enhanced broad-spectrum antibacterial activity compared with an equivalent amount of silver nitrate, owing to its increasing accessibility of released Ag to the cell walls of microorganisms. More importantly, the antibacterial system could be successfully applied to treat wound infection, while retaining high antibacterial activities, exhibiting negligible biotoxicity and avoiding the waste of Ag.
银纳米粒子（AgNPs）已被用作一种广谱抗菌剂，其毒性源于 Ag 离子的局部释放。然而，残留的 AgNPs 核可能会对人类产生潜在风险并浪费贵金属。在此，我们用最少的 Ag 离子注入半胱氨酸修饰的二硫化钼，并在其表面覆盖一层阳离子聚电解质，构建了一种高效且良性的抗菌储存库。与同等量的硝酸银相比，该系统表现出更强的广谱抗菌活性，这是由于其释放的 Ag 更易接近微生物的细胞壁。更重要的是，该抗菌系统可成功用于治疗伤口感染，同时保持高抗菌活性，表现出可忽略的生物毒性并避免 Ag 的浪费。
