Flaegstad T, Permin H, Husebekk A, Husby G, Traavik T
Department of Microbiology, University of Tromsø, Norway.
Scand J Infect Dis. 1988;20(2):145-50. doi: 10.3109/00365548809032431.
Antibodies to the human papovavirus BK (BKV) were determined in a group of 25 homo- and bisexual males with AIDS, 24 men with AIDS-related complex (ARC) and 18 healthy male homosexual controls from Copenhagen. The AIDS patients had a significantly lower prevalence and level of anti-BKV antibodies tested by IgG-ELISA, hemagglutination inhibition and neutralization tests than the ARC patients. About half of the anti-BKV antibody positive AIDS patients demonstrated primary infections or reactivations but without specific IgM production. The titers were low compared to primary infections in children. At least 2 of the patients lost their serological markers in the late phase of the disease. It is therefore possible that the low prevalence of BKV infection in AIDS patients is caused by loss of serological markers even if the level of total IgG is normal or increased.
在一组来自哥本哈根的25名患有艾滋病的同性恋和双性恋男性、24名患有艾滋病相关综合征（ARC）的男性以及18名健康男性同性恋对照者中，检测了针对人乳头瘤病毒BK（BKV）的抗体。通过IgG - ELISA、血凝抑制试验和中和试验检测发现，艾滋病患者中抗BKV抗体的患病率和水平显著低于ARC患者。大约一半抗BKV抗体呈阳性的艾滋病患者表现出原发性感染或再激活，但无特异性IgM产生。与儿童原发性感染相比，其滴度较低。至少有2名患者在疾病后期失去了血清学标志物。因此，即使总IgG水平正常或升高，艾滋病患者中BKV感染患病率低也有可能是血清学标志物丧失所致。
