血清巨噬细胞移动抑制因子与心房颤动相关。
Serum macrophage migration inhibitory factor is correlated with atrial fibrillation.
作者信息
Wan Chunfu, Li Zhihua
机构信息
Department of Pain and Rehabilitation, Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Department of Anaesthesia, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
出版信息
J Clin Lab Anal. 2018 Feb;32(2). doi: 10.1002/jcla.22225. Epub 2017 Apr 13.
Abstract
OBJECTIVE
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine secreted by macrophages. This study is performed to investigate whether serum MIF is correlated with atrial fibrillation (AF).
METHODS
Totally, 186 AF patients and 103 healthy controls were enrolled in this study. AF patients were then divided into paroxysmal AF, persistent AF, and permanent AF subgroups.
RESULTS
There were higher serum MIF concentrations in AF patients than in healthy subjects. Logistic regression analysis demonstrated that serum MIF was associated with AF. Permanent AF patients exhibited higher serum MIF concentrations than persistent and paroxysmal AF subgroups. Elevated serum MIF concentrations were found in persistent AF patients compared with paroxysmal AF patients. Moreover, serum MIF concentrations were associated with left atrial diameter after Spearman correlation analysis.
摘要
目的
巨噬细胞移动抑制因子（MIF）是一种由巨噬细胞分泌的促炎细胞因子。本研究旨在探讨血清MIF是否与心房颤动（AF）相关。
方法
本研究共纳入186例AF患者和103例健康对照。AF患者随后被分为阵发性AF、持续性AF和永久性AF亚组。
结果
AF患者血清MIF浓度高于健康受试者。逻辑回归分析表明血清MIF与AF相关。永久性AF患者血清MIF浓度高于持续性和阵发性AF亚组。与阵发性AF患者相比，持续性AF患者血清MIF浓度升高。此外，经Spearman相关性分析，血清MIF浓度与左心房直径相关。
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