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本文引用的文献

1
Catheter ablation of atrial fibrillation in very young adults: a 5-year follow-up study.房颤在非常年轻的成年人中的导管消融：5 年随访研究。
Europace. 2018 Jan 1;20(1):58-64. doi: 10.1093/europace/euw378.
2
Bariatric Surgery and the Risk of New-Onset Atrial Fibrillation in Swedish Obese Subjects.瑞典肥胖人群的减肥手术与新发心房颤动风险
J Am Coll Cardiol. 2016 Dec 13;68(23):2497-2504. doi: 10.1016/j.jacc.2016.09.940.
3
Associations of Epicardial, Abdominal, and Overall Adiposity With Atrial Fibrillation.心外膜、腹部及总体肥胖与心房颤动的关联。
Circ Arrhythm Electrophysiol. 2016 Dec;9(12). doi: 10.1161/CIRCEP.116.004378.
4
The association of plasma oxidative status and inflammation with the development of atrial fibrillation in patients presenting with ST elevation myocardial infarction.ST段抬高型心肌梗死患者血浆氧化状态和炎症与心房颤动发生的关联。
Scand J Clin Lab Invest. 2017 Apr;77(2):77-82. doi: 10.1080/00365513.2016.1244857. Epub 2016 Dec 1.
5
Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia.巨噬细胞移动抑制因子和丙二醛作为2型糖尿病血管风险并发症的潜在预测指标：沙特阿拉伯的横断面病例对照研究
Mediators Inflamm. 2016;2016:5797930. doi: 10.1155/2016/5797930. Epub 2016 May 19.
6
Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation.心房颤动的分子机制与新治疗模式
Circ Arrhythm Electrophysiol. 2016 May;9(5). doi: 10.1161/CIRCEP.115.003721.
7
Serum macrophage migration inhibitory factor levels are associated with angiographically complex coronary lesions in patients with coronary artery disease.血清巨噬细胞移动抑制因子水平与冠心病患者血管造影显示的复杂冠状动脉病变相关。
Genet Test Mol Biomarkers. 2015 Oct;19(10):556-60. doi: 10.1089/gtmb.2015.0113. Epub 2015 Aug 11.
8
Attenuation of atherosclerotic lesions in diabetic apolipoprotein E-deficient mice using gene silencing of macrophage migration inhibitory factor.利用巨噬细胞移动抑制因子基因沉默减轻糖尿病载脂蛋白E缺乏小鼠的动脉粥样硬化病变
J Cell Mol Med. 2015 Apr;19(4):836-49. doi: 10.1111/jcmm.12521. Epub 2015 Feb 8.
9
Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells.Src酪氨酸激酶和蛋白激酶C参与H2O2诱导的HL-1小鼠心肌细胞中巨噬细胞迁移抑制因子的表达。
Braz J Med Biol Res. 2013 Sep;46(9):746-51. doi: 10.1590/1414-431X20132936. Epub 2013 Sep 6.
10
Atrial fibrillation: profile and burden of an evolving epidemic in the 21st century.心房颤动：21 世纪不断演变的流行疾病特征与负担。
Int J Cardiol. 2013 Sep 1;167(5):1807-24. doi: 10.1016/j.ijcard.2012.12.093. Epub 2013 Feb 4.

血清巨噬细胞移动抑制因子与心房颤动相关。

Serum macrophage migration inhibitory factor is correlated with atrial fibrillation.

作者信息

Wan Chunfu, Li Zhihua

机构信息

Department of Pain and Rehabilitation, Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.

Department of Anaesthesia, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.

出版信息

J Clin Lab Anal. 2018 Feb;32(2). doi: 10.1002/jcla.22225. Epub 2017 Apr 13.

DOI:10.1002/jcla.22225
PMID:28407372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6817180/
Abstract

OBJECTIVE

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine secreted by macrophages. This study is performed to investigate whether serum MIF is correlated with atrial fibrillation (AF).

METHODS

Totally, 186 AF patients and 103 healthy controls were enrolled in this study. AF patients were then divided into paroxysmal AF, persistent AF, and permanent AF subgroups.

RESULTS

There were higher serum MIF concentrations in AF patients than in healthy subjects. Logistic regression analysis demonstrated that serum MIF was associated with AF. Permanent AF patients exhibited higher serum MIF concentrations than persistent and paroxysmal AF subgroups. Elevated serum MIF concentrations were found in persistent AF patients compared with paroxysmal AF patients. Moreover, serum MIF concentrations were associated with left atrial diameter after Spearman correlation analysis.

摘要

目的

巨噬细胞移动抑制因子（MIF）是一种由巨噬细胞分泌的促炎细胞因子。本研究旨在探讨血清MIF是否与心房颤动（AF）相关。

方法

本研究共纳入186例AF患者和103例健康对照。AF患者随后被分为阵发性AF、持续性AF和永久性AF亚组。

结果

AF患者血清MIF浓度高于健康受试者。逻辑回归分析表明血清MIF与AF相关。永久性AF患者血清MIF浓度高于持续性和阵发性AF亚组。与阵发性AF患者相比，持续性AF患者血清MIF浓度升高。此外，经Spearman相关性分析，血清MIF浓度与左心房直径相关。