Abboud Jean, Stein Michael, Ramien Michele, Malic Claudia
Division of Plastic Surgery, University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
Division of Dermatology, University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
Syst Rev. 2017 Apr 13;6(1):81. doi: 10.1186/s13643-017-0477-8.
Spitz nevi are uncommon melanocytic neoplasms found in children. Historically, the diagnosis and management of these tumors has lacked consensus among oncologists, pathologists, plastic surgeons, and dermatologists. Once interpreted and treated as a "juvenile melanoma", many have argued for the benignancy of such tumors in certain patient age groups, encouraging a conservative approach. The lack of consensus surrounding the diagnosis and perceived malignant potential of these tumors has led physicians to approach them on a case-by-case basis and institutional protocols. To date, no evidence-based management guideline exists. The objective of this systematic review is to both collect and appraise the evidence on the diagnosis and management of these tumors.
A comprehensive electronic literature search will be conducted in PubMed, MEDLINE, Embase, and the Cochrane Library from inception to December 2016. Our search involved collaborating with a healthcare librarian to create a strategy for the OVID/MEDLINE databases. A search of electronic databases for oncology, pathology, plastic surgery, and dermatology abstracts will be performed. Key search terms will include, among several others, "Spitz nevi," "Spitzoid melanoma," "juvenile tumor," and "pediatric". The language of publication will be restricted to English and French. Wherever data allows, meta-analyses will be used to assess differences between Spitz nevi and the tumor of comparison. Additionally, data extraction and summarization using tables will be performed. This review has been registered with PROSPERO (CRD42016034045).
This review will systematically and comprehensively review diagnostic and management practices associated with the Spitz nevus. This overview of current literature will hopefully provide the foundation for future standardization of clinical practice.
PROSPERO CRD42016034045.
斯皮茨痣是儿童中罕见的黑素细胞肿瘤。从历史上看，肿瘤学家、病理学家、整形外科医生和皮肤科医生对这些肿瘤的诊断和治疗缺乏共识。这些肿瘤曾被解释并当作“青少年黑色素瘤”进行治疗，许多人主张在某些患者年龄组中此类肿瘤为良性，鼓励采取保守治疗方法。围绕这些肿瘤的诊断和潜在恶性程度缺乏共识，导致医生根据具体病例和机构规程来处理。迄今为止，尚无基于证据的管理指南。本系统评价的目的是收集和评估关于这些肿瘤诊断和治疗的证据。
将在PubMed、MEDLINE、Embase和Cochrane图书馆进行全面的电子文献检索，检索时间从建库至2016年12月。我们的检索工作包括与一名医学图书馆员合作，制定针对OVID/MEDLINE数据库的检索策略。将对肿瘤学、病理学、整形外科学和皮肤病学的电子数据库进行检索，以获取摘要。主要检索词除其他外还将包括“斯皮茨痣”、“斯皮茨样黑色素瘤”、“青少年肿瘤”和“儿科”。发表语言将限于英语和法语。只要数据允许，将使用荟萃分析来评估斯皮茨痣与对照肿瘤之间的差异。此外，将使用表格进行数据提取和汇总。本评价已在国际前瞻性系统评价注册库（PROSPERO）注册（注册号：CRD42016034045）。
本评价将系统全面地回顾与斯皮茨痣相关的诊断和治疗实践。对当前文献的这一概述有望为未来临床实践的标准化奠定基础。
国际前瞻性系统评价注册库（PROSPERO）CRD42016034045
