从代谢物角度看肠道菌群在结直肠癌中的作用：一项系统综述

Han Shuwen, Gao Jianlan, Zhou Qing, Liu Shanshan, Wen Caixia, Yang Xi

Department of Medical Oncology, Huzhou Central Hospital.

Department of Critical Care Medicine, Huzhou Central Hospital.

Cancer Manag Res. 2018 Jan 31;10:199-206. doi: 10.2147/CMAR.S153482. eCollection 2018.

Colorectal cancer is one of the most common human malignant tumors. Recent research has shown that colorectal cancer is a dysbacteriosis-induced disease; however, the role of intestinal bacteria in colorectal cancer is unclear. This review explores the role of intestinal flora in colorectal cancer. In total, 57 articles were included after identification and screening. The pertinent literature on floral metabolites in colorectal cancer from three metabolic perspectives - including carbohydrate, lipid, and amino acid metabolism - was analyzed. An association network regarding the role of intestinal flora from a metabolic perspective was constructed by analyzing the previous literature to provide direction and insight for further research on intestinal flora in colorectal cancer.

结直肠癌是人类最常见的恶性肿瘤之一。最近的研究表明，结直肠癌是一种由肠道菌群失调引起的疾病；然而，肠道细菌在结直肠癌中的作用尚不清楚。本综述探讨了肠道菌群在结直肠癌中的作用。经过识别和筛选，共纳入57篇文章。从碳水化合物、脂质和氨基酸代谢这三个代谢角度分析了有关结直肠癌中菌群代谢产物的相关文献。通过分析以往文献构建了从代谢角度看肠道菌群作用的关联网络，为进一步研究结直肠癌中的肠道菌群提供方向和见解。