病原体相关的调节性非编码 RNA 与肿瘤发生。

Pathogen-associated regulatory non-coding RNAs and oncogenesis.

机构信息

Laboratory of Microbiology and Cell Biology, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan.

Laboratory of Microbiology and Cell Biology, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan,

出版信息

Front Biosci (Landmark Ed). 2017 Jun 1;22(10):1599-1621. doi: 10.2741/4560.

DOI:10.2741/4560

PMID:28410134

Abstract

Among all new cancer cases in 2012, on average, 15.4% were caused by or oncoviruses, including Epstein-Barr virus, human papillomavirus, , , Kaposi sarcoma-associated herpesvirus and human T-lymphotropic virus. These pathogens encode a variety of non-coding RNAs, which are important cofactors for oncogenesis. In this review, we focus on recent developments in the study of long and small non-protein-coding RNAs, including microRNAs, of oncogenic pathogens, and discuss their mechanisms of action in the multiple steps of oncogenesis.

摘要

在 2012 年所有新癌症病例中，平均有 15.4%是由病毒或致癌病毒引起的，包括 Epstein-Barr 病毒、人乳头瘤病毒、乙型肝炎病毒、丙型肝炎病毒、卡波济肉瘤相关疱疹病毒和人类 T 淋巴细胞病毒。这些病原体编码多种非编码 RNA，它们是非致癌作用的重要辅助因子。在这篇综述中，我们重点介绍了致癌病原体中长链和小非蛋白编码 RNA（包括 microRNAs）的最新研究进展，并讨论了它们在致癌作用的多个步骤中的作用机制。