Cunningham A L, Grohman G S, Harkness J, Law C, Marriott D, Tindall B, Cooper D A
Department of Virology, Westmead Hospital, Sydney, New South Wales, Australia.
J Infect Dis. 1988 Aug;158(2):386-91. doi: 10.1093/infdis/158.2.386.
Gastrointestinal viruses, predominantly rotaviruses and adenoviruses, were detected by enzyme-linked immunosorbent assay, electron microscopy, or cell culture in greater than 50% of two groups of homosexual men with symptomatic human immunodeficiency virus (HIV) infection, who did (54%) or did not (50%) have diarrhea. Lower detection rates were observed in HIV-seronegative (15%) and asymptomatic HIV-seropositive (16%) men. In the patients with diarrhea, 95% of the isolates of virus were found in the most immunosuppressed patients, those patients with AIDS-related complex or opportunistic infections associated with AIDS. High excretion rates of these viruses are probably associated with both anal-oral transmission and immunosuppression. These viruses apparently cause acute episodes or relapses of diarrhea in some patients but may be co-pathogens or noncontributory to chronic diarrhea in others.
通过酶联免疫吸附测定、电子显微镜检查或细胞培养，在两组有症状的人类免疫缺陷病毒（HIV）感染的同性恋男性中，超过50%检测到胃肠道病毒，主要是轮状病毒和腺病毒，其中一组有腹泻症状（54%），另一组无腹泻症状（50%）。在HIV血清阴性男性（15%）和无症状HIV血清阳性男性（16%）中，检测率较低。在腹泻患者中，95%的病毒分离株来自免疫抑制最严重的患者，即患有艾滋病相关综合征或与艾滋病相关的机会性感染的患者。这些病毒的高排泄率可能与肛交传播和免疫抑制都有关。这些病毒显然在一些患者中引起腹泻的急性发作或复发，但在其他患者中可能是共同病原体或与慢性腹泻无关。
