人类三叉神经节中潜伏的1型单纯疱疹病毒转录
Latent herpes simplex virus type 1 transcription in human trigeminal ganglia.
作者信息
Steiner I, Spivack J G, O'Boyle D R, Lavi E, Fraser N W
机构信息
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
出版信息
J Virol. 1988 Sep;62(9):3493-6. doi: 10.1128/JVI.62.9.3493-3496.1988.
Abstract
We studied latent herpes simplex virus type 1 gene expression in human trigeminal ganglia. Two transcripts were mapped to a 3.0-kilobase region within the long repeat region and appeared to be located in neuronal nuclei. These viral RNAs were not abundant during lytic replication and may represent an alternative pattern of herpes simplex virus type 1 gene expression involved in the pathogenesis of latent infection.
摘要
我们研究了人类三叉神经节中潜伏的1型单纯疱疹病毒基因表达。两种转录本被定位到长重复区域内一个3.0千碱基的区域，并且似乎位于神经元细胞核中。这些病毒RNA在裂解复制期间并不丰富，可能代表了1型单纯疱疹病毒基因表达的一种与潜伏感染发病机制有关的替代模式。
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