• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.哈维肉瘤病毒基因组除了癌基因ras外，不包含与其他逆转录病毒无关的大量序列。
J Virol. 1988 Sep;62(9):3540-3. doi: 10.1128/JVI.62.9.3540-3543.1988.
2
An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.哈维鼠肉瘤病毒前导序列大鼠VL30区域中的内部核糖体进入信号及其在双顺反子逆转录病毒载体中的应用。
J Virol. 1995 Oct;69(10):6400-7. doi: 10.1128/JVI.69.10.6400-6407.1995.
3
The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat.恶性组织细胞增多症肉瘤病毒，是哈维鼠肉瘤病毒和弗瑞德貂细胞集落形成病毒的重组体，通过长末端重复序列的改变获得了髓系转化特异性。
J Virol. 1990 Jan;64(1):369-78. doi: 10.1128/JVI.64.1.369-378.1990.
4
Anoxia-inducible rat VL30 elements and their relationship to ras-containing sarcoma viruses.缺氧诱导的大鼠VL30元件及其与含ras肉瘤病毒的关系。
J Virol. 1993 Nov;67(11):6857-62. doi: 10.1128/JVI.67.11.6857-6862.1993.
5
Evidence that retroviral transduction is mediated by DNA not by RNA.逆转录病毒转导由DNA而非RNA介导的证据。
Proc Natl Acad Sci U S A. 1990 May;87(9):3604-8. doi: 10.1073/pnas.87.9.3604.
6
Apparent recombinants between virus-liKE (VL30) and murine leukemia virus-related sequences in mouse DNA.小鼠DNA中病毒样（VL30）序列与鼠白血病病毒相关序列之间的明显重组体。
J Virol. 1983 Jul;47(1):178-84. doi: 10.1128/JVI.47.1.178-184.1983.
7
Harvey murine sarcoma virus: influences of coding and noncoding sequences on cell transformation in vitro and oncogenicity in vivo.哈维鼠肉瘤病毒：编码和非编码序列对体外细胞转化及体内致癌性的影响
J Virol. 1989 Mar;63(3):1384-92. doi: 10.1128/JVI.63.3.1384-1392.1989.
8
Analysis of viral and somatic activations of the cHa-ras gene.cHa-ras基因的病毒激活与体细胞激活分析。
J Virol. 1985 Jan;53(1):260-5. doi: 10.1128/JVI.53.1.260-265.1985.
9
Retroviral recombination during reverse transcription.逆转录过程中的逆转录病毒重组。
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2052-6. doi: 10.1073/pnas.87.6.2052.
10
An altered DNA sequence encompassing the ras gene of Harvey murine sarcoma virus.一段包含哈维鼠肉瘤病毒ras基因的改变的DNA序列。
Nucleic Acids Res. 1984 Jul 25;12(14):5583-8. doi: 10.1093/nar/12.14.5583.

引用本文的文献

1
Anoxia-inducible rat VL30 elements and their relationship to ras-containing sarcoma viruses.缺氧诱导的大鼠VL30元件及其与含ras肉瘤病毒的关系。
J Virol. 1993 Nov;67(11):6857-62. doi: 10.1128/JVI.67.11.6857-6862.1993.
2
An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.哈维鼠肉瘤病毒前导序列大鼠VL30区域中的内部核糖体进入信号及其在双顺反子逆转录病毒载体中的应用。
J Virol. 1995 Oct;69(10):6400-7. doi: 10.1128/JVI.69.10.6400-6407.1995.
3
Anoxic induction of a sarcoma virus-related VL30 retrotransposon is mediated by a cis-acting element which binds hypoxia-inducible factor 1 and an anoxia-inducible factor.一种与肉瘤病毒相关的VL30逆转录转座子的缺氧诱导是由一个顺式作用元件介导的，该元件可结合缺氧诱导因子1和一个缺氧诱导因子。
J Virol. 1995 Oct;69(10):6335-41. doi: 10.1128/JVI.69.10.6335-6341.1995.
4
Characterization of Moloney murine leukemia virus mutants with single-amino-acid substitutions in the Cys-His box of the nucleocapsid protein.对核衣壳蛋白的半胱氨酸-组氨酸盒中具有单氨基酸取代的莫洛尼鼠白血病病毒突变体的表征。
J Virol. 1989 Apr;63(4):1558-68. doi: 10.1128/JVI.63.4.1558-1568.1989.
5
Specificity of retroviral RNA packaging.逆转录病毒RNA包装的特异性
J Virol. 1991 Jan;65(1):71-80. doi: 10.1128/JVI.65.1.71-80.1991.

本文引用的文献

1
Discrete regions of sequence homology between cloned rodent VL30 genetic elements and AKV-related MuLV provirus genomes.克隆的啮齿动物VL30遗传元件与AKV相关的鼠白血病病毒前病毒基因组之间序列同源性的离散区域。
Nucleic Acids Res. 1983 Jan 25;11(2):305-19. doi: 10.1093/nar/11.2.305.
2
Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus.哈维氏小鼠肉瘤病毒p21转化蛋白的核苷酸序列。
Science. 1982 Sep 3;217(4563):934-6. doi: 10.1126/science.6287572.
3
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.哈维氏和克里斯滕氏肉瘤病毒的p21 src基因源自正常脊椎动物基因家族中的不同成员。
Nature. 1981 Aug 6;292(5823):506-11. doi: 10.1038/292506a0.
4
Terminal direct repeats in a retrovirus-like repeated mouse gene family.一种逆转录病毒样重复小鼠基因家族中的末端直接重复序列。
Nature. 1981 Jan 1;289(5793):83-5. doi: 10.1038/289083a0.
5
Mapping of transforming region of the Harvey murine sarcoma virus genome by using insertion-deletion mutants constructed in vitro.利用体外构建的插入缺失突变体对哈维鼠肉瘤病毒基因组的转化区域进行定位。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4674-8. doi: 10.1073/pnas.77.8.4674.
6
Heterogeneity of "virus-like" genes encoding retrovirus-associated 30S RNA and their organization within the mouse genome.编码逆转录病毒相关30S RNA的“病毒样”基因的异质性及其在小鼠基因组中的组织形式。
Cell. 1980 Jun;20(2):431-9. doi: 10.1016/0092-8674(80)90629-7.
7
Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus.逆转录病毒逆转录酶与乙型肝炎病毒及花椰菜花叶病毒假定聚合酶之间的序列同源性。
Nature. 1983;305(5937):827-9. doi: 10.1038/305827a0.
8
Structure and genomic organization of a new family of murine retrovirus-related DNA sequences (MuRRS).一种新的小鼠逆转录病毒相关DNA序列家族（MuRRS）的结构与基因组组织
Nucleic Acids Res. 1985 May 24;13(10):3461-70. doi: 10.1093/nar/13.10.3461.
9
Primer binding sites corresponding to several tRNA species are present in DNAs of different members of the same retrovirus-like gene family (VL30).对应于几种tRNA种类的引物结合位点存在于同一类逆转录病毒样基因家族（VL30）不同成员的DNA中。
J Virol. 1985 Apr;54(1):236-9. doi: 10.1128/JVI.54.1.236-239.1985.
10
BIONET: national computer resource for molecular biology.生物网络：分子生物学的国家计算机资源。
Nucleic Acids Res. 1986 Jan 10;14(1):17-20. doi: 10.1093/nar/14.1.17.

哈维肉瘤病毒基因组除了癌基因ras外，不包含与其他逆转录病毒无关的大量序列。

Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.

作者信息

Manly K F, Anderson G R, Stoler D L

机构信息

Department of Cell and Molecular Biology, Roswell Park Memorial Institute, Buffalo, New York 14263.

出版信息

J Virol. 1988 Sep;62(9):3540-3. doi: 10.1128/JVI.62.9.3540-3543.1988.

DOI:10.1128/JVI.62.9.3540-3543.1988
PMID:2841504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253486/
Abstract

The Harvey murine sarcoma virus genome contains two rat-derived sets of genetic information recombined with the Moloney mouse leukemia virus. The rat sequences represent a ras oncogene and a rat VL30 element. The VL30 sequences have several discrete regions of similarity with retroviral sequences which were detected by searching a protein database for similarities with predicted polypeptide sequences from the VL30 regions. On the 5' side, the most similar sequences were those of feline sarcoma viruses; on the 3' side, murine leukemia viruses were the most similar. Some of the regions of similarity could also be detected directly by searching a nucleic acid sequence database with the viral DNA sequences. The most extensive region of similarity was that which corresponded to the endonuclease in the pol gene of a murine leukemia virus. The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences.

摘要

哈维鼠肉瘤病毒基因组包含两组源自大鼠的遗传信息，它们与莫洛尼小鼠白血病病毒发生了重组。大鼠序列代表一个ras癌基因和一个大鼠VL30元件。通过在蛋白质数据库中搜索与VL30区域预测的多肽序列的相似性，发现VL30序列与逆转录病毒序列有几个离散的相似区域。在5'端，最相似的序列是猫肉瘤病毒的序列；在3'端，小鼠白血病病毒的序列最相似。一些相似区域也可以通过用病毒DNA序列搜索核酸序列数据库直接检测到。最广泛的相似区域对应于小鼠白血病病毒pol基因中的核酸内切酶。现在，哈维肉瘤病毒基因组中存在的大多数源自大鼠的序列可以专门归因于ras或与逆转录病毒或逆转座子相关的序列。