哈维肉瘤病毒基因组除了癌基因ras外，不包含与其他逆转录病毒无关的大量序列。
Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.
作者信息
Manly K F, Anderson G R, Stoler D L
机构信息
Department of Cell and Molecular Biology, Roswell Park Memorial Institute, Buffalo, New York 14263.
出版信息
J Virol. 1988 Sep;62(9):3540-3. doi: 10.1128/JVI.62.9.3540-3543.1988.
The Harvey murine sarcoma virus genome contains two rat-derived sets of genetic information recombined with the Moloney mouse leukemia virus. The rat sequences represent a ras oncogene and a rat VL30 element. The VL30 sequences have several discrete regions of similarity with retroviral sequences which were detected by searching a protein database for similarities with predicted polypeptide sequences from the VL30 regions. On the 5' side, the most similar sequences were those of feline sarcoma viruses; on the 3' side, murine leukemia viruses were the most similar. Some of the regions of similarity could also be detected directly by searching a nucleic acid sequence database with the viral DNA sequences. The most extensive region of similarity was that which corresponded to the endonuclease in the pol gene of a murine leukemia virus. The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences.
哈维鼠肉瘤病毒基因组包含两组源自大鼠的遗传信息，它们与莫洛尼小鼠白血病病毒发生了重组。大鼠序列代表一个ras癌基因和一个大鼠VL30元件。通过在蛋白质数据库中搜索与VL30区域预测的多肽序列的相似性，发现VL30序列与逆转录病毒序列有几个离散的相似区域。在5'端，最相似的序列是猫肉瘤病毒的序列；在3'端，小鼠白血病病毒的序列最相似。一些相似区域也可以通过用病毒DNA序列搜索核酸序列数据库直接检测到。最广泛的相似区域对应于小鼠白血病病毒pol基因中的核酸内切酶。现在，哈维肉瘤病毒基因组中存在的大多数源自大鼠的序列可以专门归因于ras或与逆转录病毒或逆转座子相关的序列。
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