13;14易位携带者中的Ph1阳性慢性髓性白血病
Ph1-positive CML in a 13;14 translocation carrier.
作者信息
Kohno S, Sandberg A A
出版信息
Med Pediatr Oncol. 1978;5(1):61-4. doi: 10.1002/mpo.2950050109.
PMID:284171
Abstract
A 63-year-old woman with Ph1-positive CML and a constitutional 13;14 Robertsonian translocation is described. The rarity of this cytogenetic combination and the significance of the D/D translocation in the genesis of the Ph1 and other chromosome anomalies in myeloproliferative disorders is briefly discussed. It is concluded that the occurrence of the two cytogenetic anomalies and the clinical states is coincidental.
摘要
本文描述了一名63岁患有Ph1阳性慢性粒细胞白血病且伴有先天性13;14罗伯逊易位的女性患者。简要讨论了这种细胞遗传学组合的罕见性以及D/D易位在骨髓增殖性疾病中Ph1和其他染色体异常发生过程中的意义。得出的结论是，这两种细胞遗传学异常与临床状态的出现是巧合。
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