Nutrition Department, University Hospital Miguel Servet, Zaragoza, Spain.
Clinical Biochemistry Department, University Hospital Miguel Servet, Zaragoza, Spain.
J Hum Nutr Diet. 2017 Dec;30(6):700-708. doi: 10.1111/jhn.12476. Epub 2017 Apr 17.
Post-prandial hypertriglyceridaemia (P-HTG) is associated with cardiovascular disease. This association is of paramount importance during menopause, which is also related to reduced high-density lipoprotein-cholesterol (HDLc) and elevated triglyceride (TG) levels. We aimed to provide a self-assesing tool to screen for P-HTG in menopausal women who were normotriglyceridaemic at fasting and adhered to a Mediterranean-style eating pattern.
We performed oral fat loading tests (OFLT) in combination with self-measurements of diurnal capillary TG at fixed time-points (DC-TG) in 29 healthy menopausal women. TG levels >220 mg dL at any given time during the OFLT served as diagnostic criteria for P-HTG. Subsequently, DC-TG profiles were examined to determine the best mealtime (breakfast, lunch or dinner), as well as optimal cut-off points to classify these women as having P-HTG according to the OFLT. Insulin resistance was defined as the upper tertile of the homeostatic model assessment of insulin resistance.
We found that, despite having normal fasting TG levels, P-HTG was highly prevalent (approximately 40%). Moreover, self-assessed 3-h post-lunch TG levels >165 mg dL increased the odds of having hypo-HDL cholesterolaemia by 14.1-fold (P = 0.026) and the odds of having insulin resistance by 31.6-fold (P = 0.007), adjusted for total fat intake in women adhering to a Mediterranean eating pattern having their highest energy intake at lunch.
Self-assessed 3-h post-lunch TG can be used to study post-prandial TG metabolism in Southern European menopausal women who are normotriglyceridaemic at fasting. Characterising an individual's post-prandial response may help menopausal women to evaluate their risk of cardiovascular disease.
餐后高甘油三酯血症（P-HTG）与心血管疾病有关。这种关联在绝经期尤为重要，因为绝经期还与高密度脂蛋白胆固醇（HDLc）降低和甘油三酯（TG）升高有关。我们旨在为空腹正常甘油三酯且遵循地中海饮食模式的绝经后妇女提供一种筛查 P-HTG 的自我评估工具。
我们对 29 名健康绝经后妇女进行了口服脂肪负荷试验（OFLT），并结合固定时间点的日间毛细血管 TG 自我测量（DC-TG）。OFLT 期间任何时间 TG 水平>220mg/dL 作为 P-HTG 的诊断标准。随后，检查 DC-TG 曲线，以确定最佳进餐时间（早餐、午餐或晚餐），并确定最佳切点，根据 OFLT 将这些妇女分类为 P-HTG。胰岛素抵抗定义为稳态模型评估的胰岛素抵抗的上三分位数。
我们发现，尽管空腹 TG 水平正常，但 P-HTG 的患病率很高（约 40%）。此外，自我评估的午餐后 3 小时 TG 水平>165mg/dL 使女性患低 HDL 胆固醇血症的几率增加 14.1 倍（P=0.026），患胰岛素抵抗的几率增加 31.6 倍（P=0.007），调整了遵循地中海饮食模式且午餐摄入最高能量的女性的总脂肪摄入量。
自我评估的午餐后 3 小时 TG 可用于研究空腹正常甘油三酯的南欧绝经后妇女的餐后 TG 代谢。描述个体的餐后反应可以帮助绝经后妇女评估其患心血管疾病的风险。
