Zhou Jing, Li Yuzhen, Sun Donglin
Department of Dermatology, Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Dermatology. 2017;233(1):30-36. doi: 10.1159/000455945. Epub 2017 Apr 19.
Psoriasis is an autoimmune disease with genetic and environmental factors. Based on the roles of STATs (signaling transducers and activators of transcription) in autoimmune diseases, it is assumed STAT gene polymorphisms are associated with psoriasis.
To study the association between STAT gene polymorphisms and psoriasis in the northeastern Chinese population.
Eight single-nucleotide polymorphisms were genotyped: rs2293152, rs3816769, rs4796793, and rs744166 in STAT3, rs7574865 and rs3024866 in STAT4, and rs324011 and rs3024974 in STAT6, using SNaPshot methods. The genotype, allele, and haplotype frequencies were compared between 400 psoriasis patients and 398 healthy individuals in northeastern China.
rs744166GG in STAT3 and rs7574865TT in STAT4 had higher frequencies in the case than the control group, suggesting these 2 genotypes increase the susceptibility to psoriasis (p < 0.05). Three haplotypes (H3, H6, and H7) were found to be associated with psoriasis in the study (p < 0.05).
These results indicate a role of STAT genes in the pathogenesis of psoriasis.
银屑病是一种受遗传和环境因素影响的自身免疫性疾病。基于信号转导及转录激活因子（STATs）在自身免疫性疾病中的作用，推测STAT基因多态性与银屑病相关。
研究中国东北人群中STAT基因多态性与银屑病的相关性。
采用SNaPshot方法对STAT3基因的rs2293152、rs3816769、rs4796793和rs744166，STAT4基因的rs7574865和rs3024866，以及STAT6基因的rs324011和rs3024974这8个单核苷酸多态性进行基因分型。比较中国东北400例银屑病患者和398例健康个体的基因型、等位基因及单倍型频率。
STAT3基因的rs744166GG和STAT4基因的rs7574865TT在病例组中的频率高于对照组，提示这两种基因型增加了患银屑病的易感性（p < 0.05）。研究发现三种单倍型（H3、H6和H7）与银屑病相关（p < 0.05）。
这些结果表明STAT基因在银屑病发病机制中起作用。
