Zhang Chen, Naman C Benjamin, Engene Niclas, Gerwick William H
Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA.
Mar Drugs. 2017 Apr 14;15(4):121. doi: 10.3390/md15040121.
A bioactivity guided study of a cf. species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands (a commonwealth of the USA), led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A (). Laucysteinamide A is a new monomeric analogue of the marine cyanobacterial metabolite, somocystinamide A (), a disulfide-bonded dimeric compound that was isolated previously from a Fijian marine cyanobacterium. The structure and absolute configuration of laucysteinamide A () was determined by a detailed analysis of its NMR, MS, and CD spectra. In addition, the highly bioactive lipid, curacin D (), was also found to be present in this cyanobacterial extract. The latter compound was responsible for the potent cytotoxicity of this extract to H-460 human non-small cell lung cancer cells in vitro.
对2013年考察期间从美国北马里亚纳群岛联邦的太平洋岛屿塞班岛采集的一种类似物种进行的生物活性导向研究，导致分离出一种新的含噻唑啉生物碱，月桂半胱氨酸酰胺A（）。月桂半胱氨酸酰胺A是海洋蓝藻代谢物索莫半胱氨酸酰胺A（）的一种新的单体类似物，索莫半胱氨酸酰胺A是一种二硫键连接的二聚化合物，先前从斐济海洋蓝藻中分离得到。通过对其核磁共振、质谱和圆二色谱的详细分析，确定了月桂半胱氨酸酰胺A（）的结构和绝对构型。此外，还发现这种蓝藻提取物中存在高生物活性脂质库拉星D（）。后一种化合物是该提取物对H-460人非小细胞肺癌细胞体外产生强细胞毒性的原因。
