在一项为期 4 年的随访研究中，EQ-5D 和 8 项帕金森病问卷（PDQ-8）的反应性。
Responsiveness of the EQ-5D and 8-item Parkinson's Disease Questionnaire (PDQ-8) in a 4-year follow-up study.
机构信息
Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Block MD3, 16 Medical Drive, Singapore, 117597 Singapore.
出版信息
Qual Life Res. 2010 May;19(4):565-9. doi: 10.1007/s11136-010-9615-7. Epub 2010 Mar 4.
OBJECTIVE
The purpose of this study was to evaluate the responsiveness of the EQ-5D and the Parkinson's Disease Questionnaire (PDQ-8) to deterioration in health-related quality of life (HRQoL) in patients with Parkinson's disease (PD).
METHODS
HRQoL and clinical data collected from 31 patients with PD (male: 74.2%, mean age: 61 years) who were surveyed with the EQ-5D and the PDQ-8 questionnaires in 2002 and 2006/2007 were analyzed. Responsiveness of the EQ-5D, PDQ-8, and Hoehn and Yahr (H&Y) staging were assessed according to Cohen's effect size (ES) and standardized response mean (SRM).
RESULTS
The mean (standard deviation) EQ-5D index and PDQ-8 summary index (PDQ-8SI) scores were 0.76 (0.23) and 17.7 (14.2) at baseline and 0.52 (0.33) and 35.1 (17.4) at year four. Based on both ES and SRM indices, the rank order of responsiveness of the studied measures, from high to low, was PDQ-8SI (ES = 1.22), EQ-5D index score (ES = 1.06), H&Y score (ES = 0.82), and the EQ-VAS score (ES = 0.24).
CONCLUSION
Both the EQ-5D and PDQ-8 are responsive to changes in health burden of the Parkinson's disease over a 4-year period.
目的
本研究旨在评估 EQ-5D 和帕金森病问卷（PDQ-8）对帕金森病（PD）患者健康相关生活质量（HRQoL）恶化的反应能力。
方法
对 2002 年和 2006/2007 年接受 EQ-5D 和 PDQ-8 问卷调查的 31 名 PD 患者（男性：74.2%，平均年龄：61 岁）的 HRQoL 和临床数据进行分析。根据 Cohen 的效应大小（ES）和标准化反应均值（SRM）评估 EQ-5D、PDQ-8 和 Hoehn 和 Yahr（H&Y）分期的反应能力。
结果
基线时，EQ-5D 指数和 PDQ-8 综合指数（PDQ-8SI）的平均值（标准差）分别为 0.76（0.23）和 17.7（14.2），四年后分别为 0.52（0.33）和 35.1（17.4）。根据 ES 和 SRM 指数，研究指标的反应能力从高到低的排序为 PDQ-8SI（ES=1.22）、EQ-5D 指数评分（ES=1.06）、H&Y 评分（ES=0.82）和 EQ-VAS 评分（ES=0.24）。
结论
EQ-5D 和 PDQ-8 在 4 年内均能敏感反映帕金森病患者的健康负担变化。
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