地果根茎中异黄酮类化合物的抗氧化及α-葡萄糖苷酶抑制活性

Antioxidant and alpha-glucosidase inhibitory activities of isoflavonoids from the rhizomes of Ficus tikoua Bur.

作者信息

Fu Guangmiao, Li Wenjuan, Huang Xiangzhong, Zhang Runzhi, Tian Kai, Hou Shuqun, Li Yukui

机构信息

a Key Laboratory of Chemistry in Ethnic Medicinal Resources , State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University , Kunming , China.

b Key Laboratory of Resource Clean Conversion in Ethnic Regions, Education Department of Yunnan , Yunnan Minzu University , Kunming , China.

出版信息

Nat Prod Res. 2018 Feb;32(4):399-405. doi: 10.1080/14786419.2017.1312391. Epub 2017 Apr 20.

DOI:10.1080/14786419.2017.1312391

PMID:28423925

Abstract

A new unique isoflavone derivatives with a cyclic-monoterpene-substituent, ficusin C (1), together with five known compounds (2-6), were isolated from the rhizomes of Ficus tikoua. Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analysis and comparison with literature data of related compounds. Antioxidant and α-glucosidase inhibitory activities of these compounds were evaluated by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay and α-glucosidase inhibitory experiment, respectively.

摘要

从地果的根茎中分离出一种具有环单萜取代基的新型独特异黄酮衍生物——无花果素C（1），以及五种已知化合物（2 - 6）。通过光谱数据解析、质谱分析并与相关化合物的文献数据进行比较，阐明了它们的结构。分别采用1,1 - 二苯基 - 2 - 苦基肼（DPPH）自由基清除法和α - 葡萄糖苷酶抑制实验对这些化合物的抗氧化活性和α - 葡萄糖苷酶抑制活性进行了评估。