Bagheri Farahani Zahra, Mirzaie Amir, Ashrafi Fatemeh, Rahimpour Hesari Maryam, Chitgar Ali, Noorbazargan Hassan, Rahimi Arian
a Department of Biology, Tehran North Branch , Islamic Azad University , Tehran , Iran.
b Young Researchers and Elite Club, East Tehran Branch , Islamic Azad University , Tehran , Iran.
Nat Prod Res. 2017 Nov;31(21):2554-2558. doi: 10.1080/14786419.2017.1318385. Epub 2017 Apr 20.
The present study aim to investigate the phytochemical composition, antibacterial, antioxidant and anticancer activities of the ethanolic extract from aerial parts of Artemisia quettensis Podlech. The aerial part of A. quettensis Podlech extract was used for Gas chromatography-mass spectrometry (GC-MS) analysis, antioxidant, antibacterial and anticancer activities. GC/MS analysis of extract from this plant showed 23 major components and the most dominant components were acetic acid, [4-(1-hydroxy-1-methylethyl) cyclohex-1-enyl] methyl ester (13.88%), trans-Phytol (10.06%) and 2,6-Dimethyl-2,6-octadiene-1,8-diol diacetate (6.8%). The extract had significant antibacterial and anticancer effects. The highest percentage of antioxidant activity was 78.46% at 2 mg/mL concentration of extract. Moreover, the highest antibacterial effects of extract were against to gram-positive bacteria and the IC cell cytotoxicity value on HT29 cell line in 24 h, 48 h and 72 h were 31.54, 6.08 and 2.96 mg/mL, respectively. From this study, A. quettensis Podlech could be considered as a promising source for novel drug compounds.
本研究旨在调查奎屯蒿地上部分乙醇提取物的植物化学成分、抗菌、抗氧化和抗癌活性。奎屯蒿地上部分提取物用于气相色谱-质谱（GC-MS）分析、抗氧化、抗菌和抗癌活性研究。该植物提取物的GC/MS分析显示有23种主要成分，其中最主要的成分是乙酸、[4-(1-羟基-1-甲基乙基)环己-1-烯基]甲酯（13.88%）、反式叶绿醇（10.06%）和2,6-二甲基-2,6-辛二烯-1,8-二醇二乙酸酯（6.8%）。该提取物具有显著的抗菌和抗癌作用。提取物浓度为2mg/mL时，抗氧化活性的最高百分比为78.46%。此外，提取物对革兰氏阳性菌的抗菌效果最佳，其对HT29细胞系在24小时、48小时和72小时的IC细胞毒性值分别为31.54mg/mL、6.08mg/mL和2.96mg/mL。从本研究来看，奎屯蒿可被视为新型药物化合物的一个有前景的来源。
