Zubaidah Elok, Rukmi Putri Widya Dwi, Puspitasari Tiara, Kalsum Umi, Dianawati Dianawati
Department of Food Science and Technology, Brawijaya University, Malang 65145, Indonesia.
Department of Pharmacology, Faculty of Health and Biomedicine, Brawijaya University, Malang 65145, Indonesia.
Int J Food Sci. 2017;2017:8742514. doi: 10.1155/2017/8742514. Epub 2017 Feb 14.
The aim of this study was to explore the potency of salacca vinegar made from various Indonesian salacca fruit extracts as therapeutic agent for hyperglycemia and dyslipidemia for STZ-induced diabetic rats. The rats were grouped into untreated rats, STZ-induced diabetic rats without treatment, and STZ-induced diabetic rats treated with Pondoh salacca vinegar, Swaru salacca vinegar, Gula Pasir salacca vinegar, Madu salacca vinegar, or Madura salacca vinegar. Parameter observed included blood glucose, total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG), malondialdehyde (MDA), superoxide dismutase (SOD), and pancreas histopathology of the samples. The results demonstrated that all salacca vinegars were capable of reducing blood sugar (from 25.1 to 62%) and reducing LDL (from 9.5 to 14.8 mg/dL), TG (from 58.3 to 69.5 mg/dL), MDA (from 1.1 to 2.2 mg/dL), and TC (from 56.3 to 70.5 mg/dL) as well as increasing HDL blood sugar of STZ-induced diabetic Wistar rats (from 52.3 to 60 mg/dL). Various salacca vinegars were also capable of regenerating pancreatic cells. Nevertheless, the ability of Swaru salacca vinegar to manage hyperglycemia and dyslipidemia appeared to be superior to other salacca vinegars. Swaru salacca vinegar is a potential therapeutic agent to manage hyperglycemia and dyslipidemia of STZ-induced diabetic rats.
本研究的目的是探索由各种印度尼西亚蛇皮果提取物制成的蛇皮果醋作为治疗链脲佐菌素诱导的糖尿病大鼠高血糖和血脂异常的治疗剂的效力。将大鼠分为未处理的大鼠、未治疗的链脲佐菌素诱导的糖尿病大鼠，以及用邦多蛇皮果醋、斯瓦鲁蛇皮果醋、古拉帕西尔蛇皮果醋、马杜蛇皮果醋或马都拉蛇皮果醋治疗的链脲佐菌素诱导的糖尿病大鼠。观察的参数包括血糖、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）、丙二醛（MDA）、超氧化物歧化酶（SOD）以及样本的胰腺组织病理学。结果表明，所有蛇皮果醋都能够降低血糖（从25.1%降至62%），降低LDL（从9.5毫克/分升降至14.8毫克/分升）、TG（从58.3毫克/分升降至69.5毫克/分升）、MDA（从1.1毫克/分升降至2.2毫克/分升）和TC（从56.3毫克/分升降至70.5毫克/分升），以及提高链脲佐菌素诱导的糖尿病Wistar大鼠的HDL血糖（从52.3毫克/分升降至60毫克/分升）。各种蛇皮果醋还能够使胰腺细胞再生。然而，斯瓦鲁蛇皮果醋控制高血糖和血脂异常的能力似乎优于其他蛇皮果醋。斯瓦鲁蛇皮果醋是治疗链脲佐菌素诱导的糖尿病大鼠高血糖和血脂异常的潜在治疗剂。
