治疗前和治疗后与健康相关的生活质量在预测脑转移患者生存方面的预后价值。
Prognostic value of pre- and post-treatment health-related quality of life in predicting survival of patients with brain metastases.
作者信息
Wong Erin, Rowbottom Leigha, Tsao May, Zhang Liying, McDonald Rachel, Danjoux Cyril, Barnes Elizabeth, Chan Stephanie, Chow Edward
机构信息
Rapid Response Radiotherapy Program, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
出版信息
CNS Oncol. 2017 Apr;6(2):119-129. doi: 10.2217/cns-2016-0020.
AIM
The present study aimed to determine the prognostic survival value of pretreatment health-related quality of life (HRQOL) and changes in HRQOL following whole-brain radiation treatment in patients with brain metastases.
METHODS
Patients who were treated with whole-brain radiation treatment and completed HRQOL questionnaires were included. Univariate and multivariate Cox proportional hazard models of overall survival (OS) were conducted for overall HRQOL and domain scores.
RESULTS & CONCLUSION: Patients with lower HRQOL at baseline, especially lower physical functioning and motor dysfunction domains, were more likely to have poorer survival. Changes in overall HRQOL and its domains were not significantly related to OS. Pretreatment HRQOL, especially physical functioning and motor dysfunction, has added prognostic value in patients with brain metastases.
目的
本研究旨在确定脑转移瘤患者全脑放射治疗前与健康相关的生活质量（HRQOL）的预后生存价值以及全脑放射治疗后HRQOL的变化。
方法
纳入接受全脑放射治疗并完成HRQOL问卷的患者。对总体HRQOL和各领域得分进行总生存（OS）的单因素和多因素Cox比例风险模型分析。
结果与结论
基线时HRQOL较低的患者，尤其是身体功能和运动功能障碍领域得分较低的患者，生存可能性更差。总体HRQOL及其各领域的变化与OS无显著相关性。治疗前的HRQOL，尤其是身体功能和运动功能障碍，对脑转移瘤患者具有额外的预后价值。
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