Jung Yong G, Lee Jun-Seok, Park Gi C
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Korea.
Laryngoscope. 2014 Nov;124(11):2456-60. doi: 10.1002/lary.24691. Epub 2014 Aug 11.
OBJECTIVES/HYPOTHESIS: Olfactory deficits that develop after viral upper respiratory infection (URI) may have different effects on patient depression index compared to chronic sinusitis with olfactory loss. However, there have been no controlled trials to evaluate the different effects of chronic sinusitis and URI on depression index.
Prospective study of 25 subjects in two groups.
This study enrolled 25 participants who were diagnosed with post-URI olfactory loss as the study group and 25 patients with chronic sinusitis and olfactory loss as a control group. Control group participants were matched for age, sex, and degree of olfactory loss (threshold, discrimination, and identification [TDI]). We compared the Beck Depression Inventory (BDI) scores of each group and analyzed the correlation between TDI and BDI.
The mean BDI score of the post-URI group was significantly higher than that of the control group (14.52 ± 6.59 vs. 9.32 ± 5.23; P=.002). Age, sex, and TDI score did not affect BDI score in the post-URI olfactory loss group. However, BDI score in the sinusitis group was inversely correlated with TDI score (R=-0.423; P=.035), and the BDI score of female subjects (11.00 ± 5.13) was significantly higher than that of male subjects (5.00 ± 2.16; P = .047).
Post-URI olfactory loss affected patient mood more severely than chronic sinusitis with a similar degree of olfactory loss. This influence was not affected by sex, age, or TDI score in the post-URI olfactory loss group.
3b.
目的/假设：与伴有嗅觉丧失的慢性鼻窦炎相比，病毒性上呼吸道感染（URI）后出现的嗅觉缺陷可能对患者抑郁指数有不同影响。然而，尚无对照试验来评估慢性鼻窦炎和URI对抑郁指数的不同影响。
对两组25名受试者进行前瞻性研究。
本研究招募了25名被诊断为URI后嗅觉丧失的参与者作为研究组，以及25名患有慢性鼻窦炎和嗅觉丧失的患者作为对照组。对照组参与者在年龄、性别和嗅觉丧失程度（阈值、辨别和识别[TDI]）方面进行了匹配。我们比较了每组的贝克抑郁量表（BDI）得分，并分析了TDI与BDI之间的相关性。
URI后组的平均BDI得分显著高于对照组（14.52±6.59对9.32±5.23；P=0.002）。年龄、性别和TDI得分在URI后嗅觉丧失组中不影响BDI得分。然而，鼻窦炎组的BDI得分与TDI得分呈负相关（R=-0.423；P=0.035），女性受试者的BDI得分（11.00±5.13）显著高于男性受试者（5.00±2.16；P=0.047）。
与嗅觉丧失程度相似的慢性鼻窦炎相比，URI后嗅觉丧失对患者情绪的影响更严重。在URI后嗅觉丧失组中，这种影响不受性别、年龄或TDI得分的影响。
3b。
