帕金森病患者肠道微生物群分析
Analysis of Gut Microbiota in Patients with Parkinson's Disease.
作者信息
Petrov V A, Saltykova I V, Zhukova I A, Alifirova V M, Zhukova N G, Dorofeeva Yu B, Tyakht A V, Kovarsky B A, Alekseev D G, Kostryukova E S, Mironova Yu S, Izhboldina O P, Nikitina M A, Perevozchikova T V, Fait E A, Babenko V V, Vakhitova M T, Govorun V M, Sazonov A E
机构信息
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2017 Apr;162(6):734-737. doi: 10.1007/s10517-017-3700-7. Epub 2017 Apr 20.
Gut microbiota of patients with Parkinson's disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson's diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.
采用细菌基因组高通量16S rRNA测序方法，对帕金森病患者和健康志愿者的肠道微生物群进行了分析。在帕金森病患者中，发现9个属和15种微生物的含量发生了变化：多雷亚菌属、拟杆菌属、普雷沃菌属、粪杆菌属、马赛拟杆菌、马西利亚斯多芬菌、粪拟杆菌、格氏布劳特氏菌、长链多雷亚菌、多雷拟杆菌、平民拟杆菌、普氏粪杆菌、真杆菌属、瘤胃球菌属含量降低，而克里斯滕森菌属、卡特巴菌属、乳酸杆菌属、颤螺菌属、双歧杆菌属、微小克里斯滕森菌、香港卡特巴菌、黏膜乳酸杆菌、布氏瘤胃球菌、肉桂食杆菌属含量增加。肠道微生物群的这种微生物学模式可引发局部炎症，随后导致α-突触核蛋白聚集并产生路易小体。
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