爱嘲笑锁匠：泛素化的 p62 解锁其自噬受体潜能。
Love laughs at Locksmiths: Ubiquitylation of p62 unlocks its autophagy receptor potential.
机构信息
Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.
出版信息
Cell Res. 2017 May;27(5):595-597. doi: 10.1038/cr.2017.56. Epub 2017 Apr 21.
Abstract
The multimodular adapter p62/sequestosome-1 plays prominent roles in physiology and disease by mediating cell signaling and cargo degradation. The work by Peng et al. published recently in Cell Research provides mechanistic insights into activation of its autophagy receptor function critical for maintaining cell homeostasis during various forms of stress.
摘要
多模块衔接蛋白 p62/自噬体相关蛋白 1 （sequestosome-1）通过介导细胞信号转导和货物降解，在生理和疾病中发挥重要作用。彭等人最近在《细胞研究》杂志上发表的工作，提供了对其自噬受体功能激活的机制见解，这对于在各种形式的应激下维持细胞内稳态至关重要。
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TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.TRIM21使SQSTM1/p62泛素化并抑制蛋白质隔离以调节氧化还原稳态。
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