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Intracellular analysis of potentiation of CA1 hippocampal synaptic transmission by phorbol ester application.

作者信息

Hvalby O, Reymann K, Andersen P

机构信息

Institute of Neurophysiology, University of Oslo, Norway.

出版信息

Exp Brain Res. 1988;71(3):588-96. doi: 10.1007/BF00248751.

DOI:10.1007/BF00248751
PMID:2843395
Abstract

(1) The effect of active and inactive phorbol esters on synaptic transmission and on membrane properties of CA1 pyramidal cells in hippocampus have been analyzed by intracellular recording. (2) 4 beta-phorbol-12,13 dibutyrate (beta PDBu), but not the alpha-isomer, increased the firing probability, reduced the spike latency and enhanced the EPSP amplitude in response to synaptic activation. The effect was similar to the changes seen in long term potentiation. After alpha PDBu addition it was possible to elicit further enhancement by tetanization, but not after beta PDBu administration. (3) A slowly developing hyperpolarization was seen after active phorbol ester application without apparent changes in the soma input resistance. (4) Active phorbol esters reduced the slow afterhyperpolarization (AHP) in these cells without affecting the intermediate AHP.

摘要

相似文献

1
Intracellular analysis of potentiation of CA1 hippocampal synaptic transmission by phorbol ester application.
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2
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3
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本文引用的文献

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Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.哺乳动物小脑切片中体外浦肯野细胞胞体的电生理特性
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
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J Neurophysiol. 1980 Feb;43(2):409-19. doi: 10.1152/jn.1980.43.2.409.
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Nature. 1984;308(5961):693-8. doi: 10.1038/308693a0.
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