Johnson Zachary V, Young Larry J
Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Neurosci Biobehav Rev. 2017 May;76(Pt A):87-98. doi: 10.1016/j.neubiorev.2017.01.034.
Oxytocin- and vasopressin-related systems are present in invertebrate and vertebrate bilaterian animals, including humans, and exhibit conserved neuroanatomical and functional properties. In vertebrates, these systems innervate conserved neural networks that regulate social learning and behavior, including conspecific recognition, social attachment, and parental behavior. Individual and species-level variation in central organization of oxytocin and vasopressin systems has been linked to individual and species variation in social learning and behavior. In humans, genetic polymorphisms in the genes encoding oxytocin and vasopressin peptides and/or their respective target receptors have been associated with individual variation in social recognition, social attachment phenotypes, parental behavior, and psychiatric phenotypes such as autism. Here we describe both conserved and variable features of central oxytocin and vasopressin systems in the context of social behavioral diversity, with a particular focus on neural networks that modulate social learning, behavior, and salience of sociosensory stimuli during species-typical social contexts.
催产素和加压素相关系统存在于包括人类在内的无脊椎动物和脊椎动物两侧对称动物中，并表现出保守的神经解剖学和功能特性。在脊椎动物中，这些系统支配着保守的神经网络，这些网络调节社会学习和行为，包括同种识别、社会依恋和父母行为。催产素和加压素系统中枢组织的个体和物种水平差异与社会学习和行为的个体和物种差异有关。在人类中，编码催产素和加压素肽及其各自靶受体的基因中的遗传多态性与社会识别、社会依恋表型、父母行为以及自闭症等精神疾病表型的个体差异有关。在这里，我们在社会行为多样性的背景下描述了中枢催产素和加压素系统的保守和可变特征，特别关注在物种典型社会背景下调节社会学习、行为和社会感觉刺激显著性的神经网络。
