Hughes Timothy M, Craft Suzanne, Baker Laura D, Espeland Mark A, Rapp Stephen R, Sink Kaycee M, Bertoni Alain G, Burke Gregory L, Gottesman Rebecca F, Michos Erin D, Luchsinger José A, Fitzpatrick Annette L, Hayden Kathleen M
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Department of Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Alzheimers Dement (Amst). 2017 Mar 31;8:18-25. doi: 10.1016/j.dadm.2017.03.003. eCollection 2017.
We examined whether changes in metabolic factors over 10 years were associated with cognitive performance.
Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000-2002) with five clinical examinations. At exam 5 (2010-2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing.
Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the ε4 allele.
Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among ε4-negative participants.
我们研究了10年间代谢因素的变化是否与认知表现相关。
自基线期（2000 - 2002年）起，对动脉粥样硬化多民族研究的参与者进行了5次临床检查。在第5次检查（2010 - 2012年）时，他们接受了简短的认知测试组合（认知能力筛查工具[CASI]、数字符号编码[DSC]和数字广度[DS]）。我们在认知测试前检查了基线代谢因素及其随时间的变化之间的关联。
在4392名参与者中，基线代谢紊乱（空腹血糖、收缩压和舒张压）与10年后测得的较差的CASI、DSC和DS分数显著相关。血压升高与较低的认知表现相关。结果在种族/民族方面没有差异，并且在没有ε4等位基因的人群中更强。
认知表现与先前存在的葡萄糖代谢异常和血压升高相关。在ε4阴性参与者中，研究结果似乎更强。
