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使用聚乙烯醇冷冻凝胶剂量计测量放射治疗中的皮肤表面剂量分布。

Measurement of skin surface dose distributions in radiation therapy using poly(vinyl alcohol) cryogel dosimeters.

作者信息

Eyadeh Molham M, Wierzbicki Marcin, Diamond Kevin R

机构信息

Physics Department, Faculty of Science, Yarmouk University, Irbid, Jordan.

Department of Medical Physics and Applied Radiation Sciences, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada.

出版信息

J Appl Clin Med Phys. 2017 May;18(3):153-162. doi: 10.1002/acm2.12087. Epub 2017 Apr 24.

Abstract

In external beam radiation therapy (EBRT), skin dose measurement is important to evaluate dose coverage of superficial target volumes. Treatment planning systems (TPSs) are often inaccurate in this region of the patient, so in vivo measurements are necessary for skin surface dose estimation. In this work, superficial dose distributions were measured using radiochromic translucent poly(vinyl alcohol) cryogels. The cryogels simultaneously served as bolus material, providing the necessary buildup to achieve the desired superficial dose. The relationship between dose to the skin surface and dose measured with the bolus was established using a series of oblique irradiations with gantry angles ranging from 0° to 90°. EBT-2 Gafchromic film was placed under the bolus, and the ratio of bolus-film dose was determined ranging from 0.749 ± 0.005 to 0.930 ± 0.002 for 0° and 90° gantry angles, respectively. The average ratio over 0-67.5° (0.800 ± 0.064) was used as the single correction factor to convert dose in bolus to dose to the skin surface. The correction factor was applied to bolus measurements of skin dose from head and neck intensity-modulated radiation therapy (IMRT) treatments delivered to a RANDO phantom. The resulting dose distributions were compared to film measurements using gamma analysis with a 3%/3 mm tolerance and a 10% threshold. The minimum gamma pass rate was 95.2% suggesting that the radiochromic bolus may provide an accurate estimation of skin surface dose using a simple correction factor. This study demonstrates the suitability of radiochromic cryogels for superficial dose measurements in megavoltage photon beams.

摘要

在体外放射治疗(EBRT)中,皮肤剂量测量对于评估浅表靶区的剂量覆盖情况非常重要。治疗计划系统(TPS)在患者的这个区域通常不准确,因此体内测量对于皮肤表面剂量估计是必要的。在这项工作中,使用放射变色半透明聚乙烯醇冷冻凝胶测量了浅表剂量分布。冷冻凝胶同时用作等效填充物,提供必要的剂量积累以实现所需的浅表剂量。通过使用一系列机架角度从0°到90°的斜向照射,建立了皮肤表面剂量与用等效填充物测量的剂量之间的关系。将EBT-2放射变色胶片置于等效填充物下方,对于0°和90°的机架角度,等效填充物 - 胶片剂量比分别确定为0.749±0.005至0.930±0.002。0 - 67.5°范围内的平均比值(0.800±0.064)用作单一校正因子,将等效填充物中的剂量转换为皮肤表面剂量。将该校正因子应用于对头颈部强度调制放射治疗(IMRT)治疗给予RANDO体模的皮肤剂量的等效填充物测量。使用3%/3 mm公差和10%阈值的伽马分析将所得剂量分布与胶片测量结果进行比较。最小伽马通过率为95.2%,表明放射变色等效填充物使用简单的校正因子可以提供皮肤表面剂量的准确估计。这项研究证明了放射变色冷冻凝胶在兆伏级光子束中进行浅表剂量测量的适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea8/5689842/21830b83766d/ACM2-18-153-g001.jpg

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