Hojman-Montes de Oca F, Dianoux L, Peries J, Emanoil-Ravicovitch R
J Virol. 1983 Apr;46(1):307-10. doi: 10.1128/JVI.46.1.307-310.1983.
Two main intracisternal-A-particle-specific RNA species (29 to 30S and 35 to 36S) are variably expressed in particle-producing and particle-nonproducing murine teratocarcinoma cell lines. An analysis of DNA methylation patterns after hybridization with an intracisternal-A-particle-specific probe showed an apparent direct correlation between DNA methylation and RNA expression. However, when the methylation assay was performed on the excised intracisternal A particle genes in one of the particle-rich cell lines (PCC6), some undermethylated sequences were detectable. These results are consistent with the concept that only few of the genes are transcriptionally active.
两种主要的脑池内A颗粒特异性RNA种类（29至30S和35至36S）在产生颗粒和不产生颗粒的小鼠畸胎瘤细胞系中表达情况各异。用脑池内A颗粒特异性探针杂交后对DNA甲基化模式进行分析，结果显示DNA甲基化与RNA表达之间存在明显的直接相关性。然而，当对其中一个富含颗粒的细胞系（PCC6）中切除的脑池内A颗粒基因进行甲基化检测时，可检测到一些低甲基化序列。这些结果与只有少数基因具有转录活性这一概念相符。
