Tiedemann K H, Hampl H, Habermehl K O
Institut für Klinische und Experimentelle Virologie, Freien Universität Berlin, Germany.
Mol Biol Rep. 1988;13(1):29-33. doi: 10.1007/BF00805636.
HEp-2 cells, which were infected with HSV-1, excrete besides other proteins a soluble glycoprotein (Mr 125,000-130,000) related to the virus protein gC. The excretion of the glycoprotein and the production of extracellular virus particles is reduced to a similar extent when the cells were treated with monensin. Possible consequences of the excretion of soluble viral proteins to a modulation of the immune response are discussed.
感染了单纯疱疹病毒1型（HSV-1）的人喉表皮样癌细胞（HEp-2细胞）除了分泌其他蛋白质外，还分泌一种与病毒蛋白gC相关的可溶性糖蛋白（分子量为125,000 - 130,000）。当用莫能菌素处理细胞时，糖蛋白的分泌和细胞外病毒颗粒的产生减少到相似的程度。文中讨论了可溶性病毒蛋白分泌对免疫反应调节的可能影响。
