Jiménez-Bravo Miguel, Marrero Victoria, Benítez-Burraco Antonio
Department of Philology, UNED, Madrid, Spain.
Department of Philology, University of Huelva, Huelva, Spain.
Behav Brain Res. 2017 Jun 30;329:84-95. doi: 10.1016/j.bbr.2017.03.048. Epub 2017 Apr 22.
Developmental dyslexia is a heterogeneous condition entailing problems with reading and spelling. Several genes have been linked or associated to the disease, many of which contribute to the development and function of brain areas important for auditory and phonological processing. Nonetheless, a clear link between genes, the brain, and the symptoms of dyslexia is still pending. The goal of this paper is contributing to bridge this gap. With this aim, we have focused on how the dyslexic brain fails to process speech sounds and reading cues. We have adopted an oscillatory perspective, according to which dyslexia may result from a deficient integration of different brain rhythms during reading/spellings tasks. Moreover, we show that some candidate genes for this condition are related to brain rhythms. This fresh approach is expected to provide a better understanding of the aetiology and the clinical presentation of developmental dyslexia, but also to achieve an earlier and more accurate diagnosis of the disease.
发育性阅读障碍是一种涉及阅读和拼写问题的异质性疾病。已有多个基因与该疾病相关联，其中许多基因对大脑中对听觉和语音处理至关重要的区域的发育和功能有影响。然而，基因、大脑与阅读障碍症状之间的明确联系仍未确定。本文的目标是有助于弥合这一差距。出于这一目的，我们专注于阅读障碍患者的大脑如何无法处理语音和阅读线索。我们采用了一种振荡视角，根据这一视角，阅读障碍可能是由于在阅读/拼写任务期间不同脑节律的整合不足所致。此外，我们表明，该疾病的一些候选基因与脑节律有关。这种新方法有望更好地理解发育性阅读障碍的病因和临床表现，同时也能实现对该疾病更早、更准确的诊断。
